ArticlePeerJ2020
Analysis of the infant gut microbiome reveals metabolic functional roles associated with healthy infants and infants with atopic dermatitis using metaproteomics.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review.Experimental dermatology · 2026Pooled it
- Clinical Proteomics Applied to Food Allergy.Advances in experimental medicine and biology · 2026Review
- Probiotics ameliorate atopic dermatitis by modulating the dysbiosis of the gut microbiota in dogs.BMC microbiology · 2025Article
- Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis.International journal of molecular sciences · 2024Article
- The new era of immune skin diseases: Exploring advances in basic research and clinical translations.Journal of translational autoimmunity · 2024Article
- The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases.International journal of molecular sciences · 2024Review
- Exploring Longitudinal Gut Microbiome towards Metabolic Functional Changes Associated in Atopic Dermatitis in Early Childhood.Biology · 2023Article
- Article
- Assessment of infant outgrowth of cow's milk allergy in relation to the faecal microbiome and metaproteome.Scientific reports · 2023Article
- Efficacy of probiotics in pediatric atopic dermatitis: A systematic review and meta-analysis.Clinical and translational allergy · 2023Review
- Gut Microbiome Proteomics in Food Allergies.International journal of molecular sciences · 2023Review
- Metabolic and inflammatory profiles, gut microbiota and lifestyle factors in overweight and normal weight young thai adults.PloS one · 2023Article
- Computational Network Inference for Bacterial Interactomics.mSystems · 2022Review
- The role of gut microbiome in inflammatory skin disorders: A systematic review.Dermatology reports · 2022Article
- ITS2 Sequencing and Targeted Meta-Proteomics of Infant Gut Mycobiome Reveal the Functional Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The infant gut microbiome consists of a complex and diverse microbial community. Comprehensive taxonomic and metabolic functional knowledge about microbial communities supports medical and biological applications, such as fecal diagnostics. Among the omics approaches available for the investigation of microbial communities, metaproteomics-based analysis is a very powerful approach; under this method, the activity of microbial communities is explored by investigating protein expression within a sample. Through use of metaproteomics, this study aimed to investigate the microbial community composition of the infant gut to identify different key proteins playing metabolic functional roles in the microbiome of healthy infants and infants with atopic dermatitis in a Thai population-based birth cohort. Here, 18 fecal samples were analyzed by liquid chromatography-tandem mass spectrometry to conduct taxonomic, functional, and pathway-based protein annotation. Accordingly, 49,973 annotated proteins out of 68,232 total proteins were investigated in gut microbiome samples and compared between the healthy and atopic dermatitis groups. Through differentially expressed proteins (DEPs) analysis, 130 significant DEPs were identified between the healthy and atopic dermatitis groups. Among these DEPs, eight significant proteins were uniquely expressed in the atopic dermatitis group. For instance, triosephosphate isomerase (TPI) in
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