ArticleChemical science2020
Late-stage and strain-accelerated oxidation enabled synthesis of haouamine A.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Dynamically Generated Carbenium Species via Photoisomerization of Cyclic Alkenes: Mild Friedel-Crafts Alkylation.The Journal of organic chemistry · 2025Article
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Authors and funding
3 authors.
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Abstract
Herein we report a new synthetic entry to the strained cyclophane alkaloid natural product, haouamine A. The successful strategy featured a rhodium-catalyzed diazo-insertion reaction to install the all-carbon quaternary center and a rhodium-catalyzed intramolecular aziridination reaction to establish the nitrogen-bearing stereocenter, of the target molecule. Most notably, a late-stage, site-selective and strain-accelerated oxidation of a "deoxygenated" macrocyclic intermediate was successfully implemented, and in doing so provided a novel solution to the infamous biphenol cyclophane system of haouamine A.
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