Evidence map›Paper›PMID 33033571›Full record

ArticleWorld journal of hepatology2020

Can gadoxetic acid-enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?

Viviane Brandão Amorim, Daniella Braz Parente, Fernando Fernandes Paiva, Jaime Araújo Oliveira Neto, Amanda Almeida Miranda, Cláudia Cravo Moreira, Flávia Ferreira Fernandes, Carlos Frederico Ferreira Campos, Nathalie Carvalho Leite, Renata de Mello Perez and 1 more

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In one paragraph

Article in World journal of hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Accuracy of Non-Invasive Imaging Techniques for the Diagnosis of MASH in Patients With MASLD: A Systematic Review.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Viviane Brandão AmorimResearch Department, D'Or Institute for Research and Education, Rio de Janeiro 22281, Brazil.
Daniella Braz ParenteResearch Department, D'Or Institute for Research and Education, Rio de Janeiro 22281, Brazil.
Fernando Fernandes PaivaSão Carlos Institute of Physics, University of São Paulo, São Carlos 13560-970, Brazil.
Jaime Araújo Oliveira NetoResearch Department, D'Or Institute for Research and Education, Rio de Janeiro 22281, Brazil.
Amanda Almeida MirandaRadiology Department, Centro de Diagnóstico Médico do Maranhão, Maranhão 65074-441, Brazil.
Cláudia Cravo MoreiraDepartment of Clinical Medicine, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Flávia Ferreira FernandesGastroenterology and Hepatology Department, Hospital Federal de Bonsucesso, Rio de Janeiro 21041-030, Brazil.
Carlos Frederico Ferreira CamposDepartment of Pathology and Laboratories, University of the State of Rio de Janeiro, Rio de Janeiro 20551-030, Brazil.
Nathalie Carvalho LeiteDepartment of Clinical Medicine, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Renata de Mello PerezResearch Department, D'Or Institute for Research and Education, Rio de Janeiro 22281, Brazil.
Rosana Souza RodriguesResearch Department, D'Or Institute for Research and Education, Rio de Janeiro 22281, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide. The diagnosis of nonalcoholic steatohepatitis (NASH), the most severe form of NAFLD, is crucial and has prognostic and therapeutic implications. However, currently this diagnosis is based on liver biopsy and has several limitations.

aimTo evaluate the performance of gadoxetic acid-enhanced magnetic resonance imaging (GA-MRI) in differentiating isolated steatosis from NASH in patients with NAFLD.

methodsIn this prospective study, 56 patients with NAFLD (18 with isolated steatosis and 38 with NASH) underwent GA-MRI. The contrast enhancement index (CEI) was calculated as the rate of increase of the liver-to-muscle signal intensity ratio from before and 20 min after intravenous GA administration. Between-group differences in mean CEI were examined using Student's

resultsThe mean CEI for all subjects was 1.82 ± 0.19. The mean CEI was significantly lower in patients with NASH than in those with isolated steatosis (

conclusionGA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis, and could help to avoid liver biopsy in patients with NAFLD.

Indexed as

Fatty liverGadoxetic acidNonalcoholic fatty liver diseaseNonalcoholic steatohepatitis

Identifiers

PMID33033571
PMCPMC7522564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.