Evidence map›Paper›PMID 33033513›Full record

ArticleJournal of Cancer2020

Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma.

Shihai Liu, Jing Qiu, Guifang He, Chao Geng, Weitai He, Changchang Liu, Duo Cai, Huazheng Pan, Qingwu Tian

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shihai LiuMedical Animal Lab, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Jing QiuDepartment of Stomatology, Qingdao Municipal Hospital, Qingdao, 266071, China.
Guifang HeMedical Animal Lab, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Chao GengDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Weitai HeSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Changchang LiuMedical Animal Lab, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Duo CaiMedical Animal Lab, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Huazheng PanDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Qingwu TianDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Qingdao University · CNAffiliated Hospital of Qingdao University · CNQingdao Municipal Hospital · CNUniversity of Jinan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a major cause of tumor associated deaths globally. Annually, the prevalence of HCC is increasing and the lack of early prognostic indicators manifests a dismal prognosis for HCC patients. A deep understanding of the molecular events that promote HCC progression are required for the design of new diagnostics and therapeutics. Dermatopontin (DPT) is an extracellular matrix protein that regulates the metastatic phenotypes of many cancers. However, the effects of DPT on HCC cell growth remain undefined. In this study, we demonstrate that the exogenous expression of DPT inhibits HCC cell growth both

Indexed as

DermatopontinHepatocellular carcinomaWnt pathway

Identifiers

PMID33033513
PMCPMC7532498
OpenAlexW3086070139

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.