Evidence map›Paper›PMID 33033486›Full record

ArticleFrontiers in psychiatry2020

Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia.

Annachiara Cagnin, Raffaele Di Lorenzo, Camillo Marra, Laura Bonanni, Chiara Cupidi, Valentina Laganà, Elisa Rubino, Alessandro Vacca, Paolo Provero, Valeria Isella and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 9 pooled it
30.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 9 syntheses or guidelines pooled it, 380 citations in OpenAlex.

  1. Examining the lived experience of dementia with Lewy bodies through qualitative research: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  11. COVID-19 Factors Associated With Medication Changes Among Nursing Home Residents With Dementia.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 1 country.

Annachiara CagninDepartment of Neuroscience (DNS), University of Padua, Padua, Italy.
Raffaele Di LorenzoRegional Neurogenetic Centre, Department of Primary Care, ASP-CZ, Catanzaro, Italy.
Camillo MarraMemory Clinic, Fondazione Policlinico Gemelli, IRCCS Università, Cattolica del Sacro Cuore, Rome, Italy.
Laura BonanniDepartment of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Chiara CupidiCDCD Ospedale del Delta, AUSL Ferrara, Ferrara, Italy.
Valentina LaganàRegional Neurogenetic Centre, Department of Primary Care, ASP-CZ, Catanzaro, Italy.
Elisa RubinoDepartment of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
Alessandro VaccaAging Brain and Memory Clinic, Department of Neuroscience, University of Torino, Turin, Italy.
Paolo ProveroDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.
Valeria IsellaDepartment of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano - Bicocca, Monza, Italy.
Nicola VanacoreNational Institute of Health, Rome, Italy.
Federica AgostaDivision of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ildebrando AppollonioDepartment of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano - Bicocca, Monza, Italy.
Paolo CaffarraUnit of Neuroscience, University of Parma, Parma, Italy.
Ilaria PettenuzzoDepartment of Neuroscience (DNS), University of Padua, Padua, Italy.
Renato SambatiDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari, Bari, Italy.
Davide QuarantaMemory Clinic, Fondazione Policlinico Gemelli, IRCCS Università, Cattolica del Sacro Cuore, Rome, Italy.
Valeria GuglielmiMemory Clinic, Fondazione Policlinico Gemelli, IRCCS Università, Cattolica del Sacro Cuore, Rome, Italy.
Giancarlo LogroscinoDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari, Bari, Italy.
Massimo FilippiDivision of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Gioacchino TedeschiDepartment of Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Carlo FerrareseDepartment of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano - Bicocca, Monza, Italy.
Innocenzo RaineroAging Brain and Memory Clinic, Department of Neuroscience, University of Torino, Turin, Italy.
Amalia C BruniRegional Neurogenetic Centre, Department of Primary Care, ASP-CZ, Catanzaro, Italy.
SINdem COVID-19 Study Group
Università Cattolica del Sacro Cuore · ITUniversity of Milano-Bicocca · ITUniversity of Turin · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleUniversity of Bari Aldo Moro · ITUniversity of Padua · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Unità Sanitaria Locale di Ferrara · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Chieti-Pescara · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been poorly investigated. The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia and their caregivers.

methodsThis is a sub-study of a multicenter nation-wide survey. A structured telephone interview was delivered to family caregivers of patients with diagnosis of Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and vascular dementia (VD), followed regularly at 87 Italian memory clinics. Variations in behavioral and psychological symptoms (BPSD) were collected after 1 month since quarantine declaration and associations with disease type, severity, gender, and caregiver's stress burden were analyzed.

resultsA total of 4,913 caregivers participated in the survey. Increased BPSD was reported in 59.6% of patients as worsening of preexisting symptoms (51.9%) or as new onset (26%), and requested drug modifications in 27.6% of these cases. Irritability, apathy, agitation, and anxiety were the most frequently reported worsening symptoms and sleep disorder and irritability the most frequent new symptoms. Profile of BPSD varied according to dementia type, disease severity, and patients' gender. Anxiety and depression were associated with a diagnosis of AD (OR 1.35, CI: 1.12-1.62), mild to moderate disease severity and female gender. DLB was significantly associated with a higher risk of worsening hallucinations (OR 5.29, CI 3.66-7.64) and sleep disorder (OR 1.69, CI 1.25-2.29), FTD with wandering (OR 1.62, CI 1.12-2.35), and change of appetite (OR 1.52, CI 1.03-2.25). Stress-related symptoms were experienced by two-thirds of caregivers and were associated with increased patients' neuropsychiatric burden (p<0.0001).

conclusionQuarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers. Health services need to plan a post-pandemic strategy in order to address these emerging needs.

Indexed as

behavioral and psychological symptomsbehavioral symptomscaregivercoronavirus diseasedementiagenderpsychological symptomsquarantine

Identifiers

PMID33033486
PMCPMC7509598
OpenAlexW3083947970

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.