Evidence map›Paper›PMID 33033462›Full record

ArticleJournal of carcinogenesis2020

Assessment of monoamine neurotransmitters in the cortex and cerebellum of gamma-irradiated mice: A neuromodulatory role of

Roopesh Poojary, Nayanatara Arun Kumar, Reshma Kumarchandra, Ganesh Sanjeev, D Shivananda Pai, N A Vinodini, K Bhagyalakshmi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of carcinogenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roopesh PoojaryDepartment of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Nayanatara Arun KumarDepartment of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Reshma KumarchandraDepartment of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Ganesh SanjeevMicrotron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, Karnataka, India.
D Shivananda PaiDepartment of Neurology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
N A VinodiniDepartment of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
K BhagyalakshmiDepartment of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Manipal Academy of Higher Education · INMangalore University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRadiation is an important tool in the diagnostic and curative treatment of many cancers. Ionizing radiation induces many biochemical changes in the cells. The present study was designed to estimate the level of neurotransmitters in the distinct brain tissue of Swiss albino mice before exposing gamma radiation. MATERIALS AND

methodsThe mice were treated with 0.25 and 1 g/kg body weight of

resultsMice exposed to a sublethal dose 5 Gy of gamma radiation causes a significant decrease in dopamine, norepinephrine, epinephrine, and serotonin levels compared to normal. The mice treated with 0.25 and 1 g/kg body weight of CDE via oral gavage for 7 days showed significant improvement in the level of monoamine neurotransmitters in both the cortex and cerebellum homogenate.

conclusionOral administration of antioxidant-rich

Indexed as

CerebellumcortexCynodon dactylongamma radiationneurotransmittersoxidative stress

Identifiers

PMID33033462
PMCPMC7511894
OpenAlexW3037280501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.