Evidence map›Paper›PMID 33033461›Full record

ArticleJournal of carcinogenesis2020

Evaluation of platelet distribution width as novel biomarker in gall bladder cancer.

Rohik Anjum T Siddeek, Amit Gupta, Sweety Gupta, Bela Goyal, Arvind Kumar Gupta, Saumya Agrawal, Ravi Roshan, Utkarsh Kumar, Navin Kumar, Manoj Gupta and 2 more

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In one paragraph

Article in Journal of carcinogenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rohik Anjum T SiddeekDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Amit GuptaDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Sweety GuptaDepartment of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Bela GoyalDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Arvind Kumar GuptaDepartment of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Saumya AgrawalDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Ravi RoshanDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Utkarsh KumarDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Navin KumarDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Manoj GuptaDepartment of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Sanjeev KishoreDepartment of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Ravi KantDepartment of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGall bladder cancer (GBC) tends to present in advanced stages, therefore, early diagnosis of GBC is necessary. There is no ideal single tumor marker available presently for the diagnosis and prognosis of GBC. Platelet distribution width (PDW) is an early marker for activated platelets and has been used in a variety of tumors to assess prognosis. This study was designed to evaluate the utility of PDW in identifying GBC patients and its association with tumor markers, staging and resectability of GBC. MATERIALS AND

methodsThis cross sectional study was done on 100 patients of GBC and 100 age- and sex- matched healthy controls. PDW was evaluated and compared between GBC and healthy controls. Receiver-operating characteristics was plotted to determine optimal cut-off for identifying GBC patients and to determine sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PDW. Correlation between serum tumor markers (carbohydrate antigen 19-9, carcinoembryonic antigen, and carbohydrate antigen 125) and PDW were evaluated. Association of PDW with hyperbilirubinemia, staging and resectability of GBC was also studied.

resultsA significantly higher PDW with a median of 18.1 was observed in GBC as compared to healthy controls with median value of 13. PDW was found to have a very high sensitivity (90%), specificity (95%), PPV (94%) and NPV (90%) in identifying GBC at cut-off of 16 with area under the curve (AUC) of 0.97. An increase of PDW was observed with increasing stage and unresectable GBC. However, it was not statistically significant. Significant positive correlation was observed between PDW and all three serum tumor markers and good positive correlation with

conclusionPDW was associated with GBC and may be considered as a cost- effective marker in adjunct to other investigations for the diagnosis of GBC.

Indexed as

Gall bladder cancerplatelet distribution widthresectabilitytumor markers

Identifiers

PMID33033461
PMCPMC7511895

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