Evidence map›Paper›PMID 33033457›Full record

ArticleJournal of medical biochemistry2020

Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism.

Koca Arzu Or, Murat Dağdeviren, Tolga Akkan, İhsan Ateş, Salim Neşelioğlu, Özcan Erel, Mustafa Altay

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In one paragraph

Article in Journal of medical biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Thiol-Disulfide Homeostasis in Skin Diseases.Journal of clinical medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Koca Arzu OrUniversity of Health Sciences, Keçiören Health Administration and Research Centre, Department of Endocrinology and Metabolism, Ankara, Turkey.
Murat DağdevirenUniversity of Health Sciences, Keçiören Health Administration and Research Centre, Department of Endocrinology and Metabolism, Ankara, Turkey.
Tolga AkkanUniversity of Health Sciences, Keçiören Health Administration and Research Centre, Department of Endocrinology and Metabolism, Ankara, Turkey.
İhsan AteşUniversity of Health Sciences, Numune Health Administration and Research Centre, Department of Internal Medicine, Ankara, Turkey.
Salim NeşelioğluUniversity of Ankara Yıldırım Beyazıt, Department of Medical Biochemistry, Ankara, Turkey.
Özcan ErelUniversity of Ankara Yıldırım Beyazıt, Department of Medical Biochemistry, Ankara, Turkey.
Mustafa AltayUniversity of Health Sciences, Keçiören Health Administration and Research Centre, Department of Endocrinology and Metabolism, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels.

methods55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples.

resultsIn our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated.

conclusionsConsequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study.

Indexed as

disulfidehypoparathyroidismparaoxonasethioltotal antioxidant statustotal oxidant status

Identifiers

PMID33033457
PMCPMC7526012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.