ArticleJournal of medical biochemistry2020
Saliva diagnostic utility in patients with type 2 diabetes: Future standard method.
Article in Journal of medical biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Salivary Biomarkers Associated with Psychological Alterations in Patients with Diabetes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders.Diabetes, obesity & metabolism · 2026Review
- C-Reactive Protein in Saliva as a Non-Invasive Marker of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Salivary Glucose Testing for Diabetes Mellitus: A Systematic Review and Meta-Analysis of Current Evidence and Methodological Heterogeneity.Journal of clinical medicine · 2026Review
- Exploring the impact of advanced glycation end products on diabetic salivary gland dysfunctions.Glycoconjugate journal · 2025Review
- Metformin Increases Serum Isthmin-1 Levels and Lowers Low-Density Lipoprotein: Potential Implications for Lipid Metabolism in T2DM.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring Saliva as a Sample for Non-Invasive Glycemic Monitoring in Diabetes: A Scoping Review.Biomedicines · 2025Review
- Correlational analysis between salivary and blood glucose levels in individuals with and without diabetes mellitus: a cross-sectional study.Acta odontologica Scandinavica · 2024Article
- A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes.Biosensors · 2023Article
- [Latest Research Findings on Health Management Based on Saliva Testing].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Changes in salivary biomarkers associated with periodontitis and diabetic neuropathy in individuals with type 1 diabetes.Scientific reports · 2022Article
- Implication of Salivary Biochemical Parameters for Diagnosis and Prognosis of Type 2 Diabetes Mellitus.International journal of analytical chemistry · 2022Article
- Salivary alpha-amylase-biomarker for monitoring type II diabetes.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the present study was to assess saliva reliability in diagnosis and monitoring type 2 diabetes instead of blood.
methodsBlood and unstimulated whole saliva were collected from 300 type 2 diabetic subjects and 300 healthy controls in fasting. Then, the salivary flow rate was calculated. All parameters including glucose, urea, amylase, total protein, albumin, C-reactive protein (CRP), immunoglobulin A (IgA), potassium, calcium and chloride were assessed in the supernatant, using an autoanalyzer. Oral exam was conducted by a single examiner on full mouth excluding third molars. Statistical analysis was performed by the SPSS 20.0 version.
resultsSaliva screening showed that glucose, urea, amylase, total protein, potassium, calcium and chloride were significantly higher in patients compared to controls (p < 0.05). Whereas, the IgA level and salivary flow rate were significantly reduced in patients (p < 0.05). No significant difference was found in albumin and CRP levels (p > 0.05). There was a significant positive correlation between salivary and plasma glucose levels (r = 0.887, and r = 0.900, p < 0.001), as well as, salivary and blood urea (r = 0.586, and r = 0.688, p < 0.001) in patients and controls, respectively.
conclusionsFrom this study, saliva could be suggested as a useful diagnostic tool for type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.