Evidence map›Paper›PMID 33033318›Full record

ArticleScientific reports2020

Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice.

Christina Charles-Schoeman, Jennifer Wang, Ani Shahbazian, Yuen Yin Lee, Xiaoyan Wang, Victor Grijalva, Ernest Brahn, Diana M Shih, Asokan Devarajan, Christy Montano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Metabolic Consequences of Rheumatoid Arthritis.Arthritis care & research · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Christina Charles-SchoemanDivision of Rheumatology, Department of Medicine, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA. ccharles@mednet.ucla.edu.
Jennifer WangDivision of Rheumatology, Department of Medicine, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Ani ShahbazianDivision of Rheumatology, Department of Medicine, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Yuen Yin LeeDivision of Rheumatology, Department of Medicine, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Xiaoyan WangDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Victor GrijalvaDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Ernest BrahnDivision of Rheumatology, Department of Medicine, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Diana M ShihDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Asokan DevarajanUCLA Cardiac Arrhythmia Center, Neurocardiology Research Center of Excellence, Los Angeles, CA, USA.
Christy MontanoDivision of Rheumatology, Department of Medicine, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Aldons J LusisDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Srinivasa T ReddyDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · USInstitute of Human Genetics · PL

Funding

Systems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0M
Mechanisms Linking Joint Inflammation and Atherosclerosis in Rheumatoid ArthritisR01HL123064 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHARLES-SCHOEMAN, CHRISTINA · 2015 to 2019
$2.7M
NHLBI NIH HHS R01 HL123064NHLBI NIH HHS R01 HL147883
6 · The paper itself

Abstract

Paraoxonase 1(PON1) is an HDL-associated protein, which metabolizes inflammatory, oxidized lipids associated with atherosclerotic plaque development. Because oxidized lipid mediators have also been implicated in the pathogenesis of rheumatoid arthritis (RA), we evaluated the role of PON1 in murine inflammatory arthritis. K/BxN serum transfer (STIA) or collagen antibody transfer (CAIA) was used for arthritis induction in B6 mice homozygous for the PON1 human transgene [PON1Tg], PON1 knock-out mice [PON1KO], and wild type littermate control mice [WT]. Experiments were also performed in K/BxN mice with chronic arthritis, and in RA patients and healthy controls. Arthritis activity in K/BxN mice was associated with a marked dyslipidemia, lower PON1 activity and higher bioactive lipid mediators (BLM), as well as a dysregulated hepatic lipid gene expression profile. Higher serum PON1 activity correlated with lower BLM and lower arthritis activity in both K/BxN mice and RA patients. Overexpression of the human PON1 transgene was associated with reduced inflammatory arthritis, which correlated strongly with higher circulating PON1 activity, upregulation of the hepatic glutathione pathway, and reduction of circulating BLM. These results implicate PON1 as a potential novel therapeutic target for joint disease in RA with potential for vascular benefit, which warrants further investigation.

Indexed as

Gene ExpressionAnimalsArthritis, RheumatoidAryldialkylphosphataseChronic DiseaseDyslipidemiasGlutathioneHumansInflammationLiverMice, TransgenicMolecular Targeted TherapySignal TransductionTransgenesAryldialkylphosphataseGlutathionePON1 protein, human

Identifiers

PMID33033318
PMCPMC7546628
OpenAlexW3092583972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.