ArticleScientific reports2020
Rewiring of gene expression in circulating white blood cells is associated with pregnancy outcome in heifers (Bos taurus).
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Network-based multi-omics approaches to identify molecular signatures associated with pregnancy status in beef heifers.Frontiers in genetics · 2026Article
- The Maternal Blood Transcriptome Reflects Changes in Fetal Growth and Is an Accurate Predictor of Birth Weight in Cattle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Transcriptome profiles of blastocysts originating from oocytes matured in follicular fluid from preovulatory follicles of greater or lesser maturity.BMC genomics · 2025Article
- Gene profiles of peripheral white blood cells as potential predictors of pregnancy in embryo-recipient heifers.PloS one · 2025Article
- Higher abundance of 2-dehydro-d-gluconate in the plasma of sub-fertile or infertile Bos taurus heifers.Journal of animal science · 2024Article
- Harnessing Genomics and Transcriptomics Approaches to Improve Female Fertility in Beef Cattle-A Review.Animals : an open access journal from MDPI · 2023Review
- A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus).Scientific reports · 2023Article
- Robust identification of regulatory variants (eQTLs) using a differential expression framework developed for RNA-sequencing.Journal of animal science and biotechnology · 2023Article
- mRNA Signatures in Peripheral White Blood Cells Predict Reproductive Potential in Beef Heifers at Weaning.Genes · 2023Article
- Sexing of cattle embryos using RNA-sequencing data or polymerase chain reaction based on a complete sequence of cattle chromosome Y.Frontiers in genetics · 2023Article
- Machine Learning-Based Co-Expression Network Analysis Unravels Potential Fertility-Related Genes in Beef Cows.Animals : an open access journal from MDPI · 2022Article
- Co-Expression Network and Integrative Analysis of Metabolome and Transcriptome Uncovers Biological Pathways for Fertility in Beef Heifers.Metabolites · 2022Article
- Delayed processing of blood samples impairs the accuracy of mRNA-based biomarkers.Scientific reports · 2022Article
- Article
- Application of PCR-HRM method for microsatellite polymorphism genotyping in the LDHA gene of pigeons (Columba livia).PloS one · 2021Article
- Rewiring of gene expression in circulating white blood cells is associated with pregnancy outcome in heifers (Bos taurus).Scientific reports · 2020Article
- Beef heifer fertility: importance of management practices and technological advancements.Journal of animal science and biotechnology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a challenging phenomenon in cattle that reduces the sustainability of beef production worldwide. Here, we tested the hypothesis that gene expression profiles of protein-coding genes expressed in peripheral white blood cells (PWBCs), and circulating micro RNAs in plasma, are associated with female fertility, measured by pregnancy outcome. We drew blood samples from 17 heifers on the day of artificial insemination and analyzed transcript abundance for 10,496 genes in PWBCs and 290 circulating micro RNAs. The females were later classified as pregnant to artificial insemination, pregnant to natural breeding or not pregnant. We identified 1860 genes producing significant differential coexpression (eFDR < 0.002) based on pregnancy outcome. Additionally, 237 micro RNAs and 2274 genes in PWBCs presented differential coexpression based on pregnancy outcome. Furthermore, using a machine learning prediction algorithm we detected a subset of genes whose abundance could be used for blind categorization of pregnancy outcome. Our results provide strong evidence that transcript abundance in circulating white blood cells is associated with fertility in heifers.
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