ArticleNature communications2020
GABAergic motor neurons bias locomotor decision-making in C. elegans.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Cell body clustering drives gap junction-mediated synchronous activity in command neurons.bioRxiv : the preprint server for biology · 2026Article
- Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans.Nature communications · 2026Article
- Excitatory GABA receptors shape locomotor circuit organization in C. elegans.Scientific reports · 2026Article
- Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- FLP-15 modulates the amplitude of body-bends during locomotion inOpen biology · 2025Article
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- Article
- Spatiotemporal dynamics of locomotor decisions inbioRxiv : the preprint server for biology · 2024Article
- RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Antioxidant and Neuroprotective Effects of Seed Oils fromAntioxidants (Basel, Switzerland) · 2024Article
- How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity.Neurotoxicology · 2024Review
- Nicotine Motivated Behavior inInternational journal of molecular sciences · 2024Article
- Invertebrate genetic models of amyotrophic lateral sclerosis.Frontiers in molecular neuroscience · 2024Review
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
- Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.PloS one · 2024Article
- Locomotion modulates olfactory learning through proprioception in C. elegans.Nature communications · 2023Article
- Why it hurts: with freedom comes the biological need for pain.Animal cognition · 2023Article
- Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans.Nature communications · 2023Article
- All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals.Nature communications · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Proper threat-reward decision-making is critical to animal survival. Emerging evidence indicates that the motor system may participate in decision-making but the neural circuit and molecular bases for these functions are little known. We found in C. elegans that GABAergic motor neurons (D-MNs) bias toward the reward behavior in threat-reward decision-making by retrogradely inhibiting a pair of premotor command interneurons, AVA, that control cholinergic motor neurons in the avoidance neural circuit. This function of D-MNs is mediated by a specific ionotropic GABA receptor (UNC-49) in AVA, and depends on electrical coupling between the two AVA interneurons. Our results suggest that AVA are hub neurons where sensory inputs from threat and reward sensory modalities and motor information from D-MNs are integrated. This study demonstrates at single-neuron resolution how motor neurons may help shape threat-reward choice behaviors through interacting with other neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.