Evidence map›Paper›PMID 33033233›Full record

ArticleCell death & disease2020

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein.

Bahareh Torkzaban, Kalimuthusamy Natarajaseenivasan, Taha Mohseni Ahooyi, Masoud Shekarabi, Shohreh Amini, T Dianne Langford, Kamel Khalili

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bahareh TorkzabanDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.ORCID http://orcid.org/0000-0003-2757-0751
Kalimuthusamy NatarajaseenivasanDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.
Taha Mohseni AhooyiDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.
Masoud ShekarabiDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.
Shohreh AminiDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.
T Dianne LangfordDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.
Kamel KhaliliDepartment of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA. kamel.khalili@temple.edu.
Temple University · US

Funding

Project 3 Dysregulation of metabolic communication of oligodendrocytes and neurons by cocaine and TatP01DA037830 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KHALILI, KAMEL · 2015 to 2019
$7.4M
HIV modulation of BAG3 impacting quality control of Tau in neuronal cellsR01AG060962 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI KHALILI, KAMEL · 2018 to 2022
$2.0M
NIA NIH HHS R01 AG060962NIDA NIH HHS P01 DA037830
6 · The paper itself

Abstract

HIV-1 Tat is a potent neurotoxic protein that is released by HIV-1 infected cells in the brain and perturbs neuronal homeostasis, causing a broad range of neurological disorders in people living with HIV-1. Furthermore, the effects of Tat have been addressed in numerous studies to investigate the molecular events associated with neuronal cells survival and death. Here, we discovered that exposure of rat primary neurons to Tat resulted in the up-regulation of an uncharacterized long non-coding RNA (lncRNA), LOC102549805 (lncRNA-U1). Our observations showed that increased expression of lncRNA-U1 in neurons disrupts bioenergetic pathways by dysregulating homeostasis of Ca

Indexed as

AnimalsAutophagyCells, CulturedCell SurvivalHIV-1MitochondriaNeuronsNeurotoxicity SyndromesRatsRNA, Long Noncodingtat Gene Products, Human Immunodeficiency VirusRNA, Long Noncodingtat Gene Products, Human Immunodeficiency Virus

Identifiers

PMID33033233
PMCPMC7546609
OpenAlexW3091997080

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.