ArticleScience (New York, N.Y.)2020
Alternating sequences of future and past behavior encoded within hippocampal theta oscillations.
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Navigational strategy dictates hippocampal representation of space in an everyday memory task.Nature communications · 2026Article
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Naturalistic behavior and self-generated neural activity predictive of self-correction.bioRxiv : the preprint server for biology · 2026Article
- Article
- Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain.Neuron · 2025Article
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- Internal and external codes for location.Nature neuroscience · 2025Article
- Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells.Nature neuroscience · 2025Article
- Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Direct entorhinal control of CA1 temporal coding.Nature communications · 2025Article
- New information triggers prospective codes to adapt for flexible navigation.Nature communications · 2025Article
- Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences.eLife · 2025Article
- Human neural dynamics of real-world and imagined navigation.Nature human behaviour · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.PLoS biology · 2025Article
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Context changes retrieval of prospective outcomes during decision deliberation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context.Nature communications · 2024Article
- Humans adaptively deploy forward and backward prediction.Nature human behaviour · 2024Article
- Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus.Annual review of neuroscience · 2024Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
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Abstract
Neural networks display the ability to transform forward-ordered activity patterns into reverse-ordered, retrospective sequences. The mechanisms underlying this transformation remain unknown. We discovered that, during active navigation, rat hippocampal CA1 place cell ensembles are inherently organized to produce independent forward- and reverse-ordered sequences within individual theta oscillations. This finding may provide a circuit-level basis for retrospective evaluation and storage during ongoing behavior. Theta phase procession arose in a minority of place cells, many of which displayed two preferred firing phases in theta oscillations and preferentially participated in reverse replay during subsequent rest. These findings reveal an unexpected aspect of theta-based hippocampal encoding and provide a biological mechanism to support the expression of reverse-ordered sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.