ArticleScience (New York, N.Y.)2020
The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
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Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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37 citing papers in PubMed, 76 citations in OpenAlex.
- Alignment-free integration of single-nucleus ATAC-seq across species with sPYce.Nature ecology & evolution · 2026Article
- Topological mixing and irreversibility in animal chromosome evolution.Science advances · 2026Article
- Evolution of CTCF binding sites in the human genome.Molecular biology and evolution · 2026Article
- Subterranean Traits of the Visual System in Mandarin Voles (Lasiopodomys mandarinus): Structural Remodeling and Functional Degeneration.Integrative zoology · 2026Article
- Supporting-like cells constitute an alternative steroidogenic lineage conserved in amniotes.bioRxiv : the preprint server for biology · 2026Article
- Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs.Nature structural & molecular biology · 2026Article
- Integrative transcriptomics nominates a 1R-MYB candidate associated with epidermal wax-related traits and osmotic-stress responses in Kentucky bluegrass.Frontiers in plant science · 2026Article
- Linking phenotype to genotype using comprehensive genomic comparisons.Current opinion in genetics & development · 2025Review
- Molecular Method Based on Hydrolysis Probe Assays to Identify the Sex Chromosomes of Iberian Desman (Galemys pyrenaicus) Using Non-Invasive Sampling.Integrative zoology · 2025Article
- Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development.Nature ecology & evolution · 2025Article
- Genome Mountaineering: Expanding Horizons of the 3D Genome for the Intrepid Evolutionary Adventurer.Genome biology and evolution · 2025Review
- The application of irreversible genomic states to define and trace ancient cell type homologies.EvoDevo · 2025Article
- Chromosome-level genome assembly of the short-faced mole (Scaptochirus moschatus).Scientific data · 2025Article
- Multiplex generation and single-cell analysis of structural variants in mammalian genomes.Science (New York, N.Y.) · 2025Article
- Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease.bioRxiv : the preprint server for biology · 2024Article
- Review
- Levels of Sex Steroids in Plethodontid Salamanders: A Comparative Study Within the GenusEcology and evolution · 2024Article
- Specificity of Key Sex Determination Genes in a Mammal with Ovotestes: The European MoleAnimals : an open access journal from MDPI · 2024Article
- TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene.Nature communications · 2024Article
- Multiplex generation and single cell analysis of structural variants in a mammalian genome.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
29 authors at 11 institutions in 5 countries.
Francisca M RealRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0003-0692-2260
Stefan A HaasDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0003-3418-3688
Paolo FranchiniChair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.ORCID 0000-0002-8184-1463
Peiwen XiongChair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.ORCID 0000-0002-8346-9132
Oleg SimakovDepartment of Molecular Evolution and Development, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-3585-4511
Heiner KuhlDepartment of Ecophysiology and Aquaculture, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany.ORCID 0000-0001-7623-9227
Robert SchöpflinRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
David HellerDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0001-8346-9565
M-Hossein MoeinzadehDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-6787-3047
Verena HeinrichDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0001-9775-3276
Thomas KrannichDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-5525-1849
Annkatrin BressinDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-3170-4823
Michaela F HartmannSteroid Research & Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics in Paediatric Endocrinology, Division of Paediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany.ORCID 0000-0001-7232-9532
Stefan A WudySteroid Research & Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics in Paediatric Endocrinology, Division of Paediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany.ORCID 0000-0002-7163-5957
Dina K N DechmannDepartment of Migration and Immuno-Ecology, Max Planck Institute for Animal Behavior, Radolfzell, Germany.ORCID 0000-0003-0043-8267
Alicia HurtadoDepartamento de Genética, Universidad de Granada, Granada, Spain.ORCID 0000-0001-6267-704X
Francisco J BarrionuevoDepartamento de Genética, Universidad de Granada, Granada, Spain.ORCID 0000-0003-2651-1530
Magdalena SchindlerRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0003-3363-1864
Izabela HarabulaRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-9094-0519
Marco OsterwalderEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.ORCID 0000-0002-1969-2313
Michael HillerMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.ORCID 0000-0003-3024-1449
Lars WittlerDepartment of Developmental Genetics, Transgenic Unit, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.ORCID 0000-0002-4130-7784
Bernd TimmermannRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Axel MeyerChair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.ORCID 0000-0002-0888-8193
Martin VingronDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-1765-4241
Rafael JiménezDepartamento de Genética, Universidad de Granada, Granada, Spain.
Stefan MundlosRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany. mundlos@molgen.mpg.de dario.lupianez@mdc-berlin.de.ORCID 0000-0002-9788-3166
Darío G LupiáñezRG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany. mundlos@molgen.mpg.de dario.lupianez@mdc-berlin.de.ORCID 0000-0002-3165-036X
Max Planck Institute for Molecular Genetics · DEUniversity of Konstanz · DEUniversidad de Granada · ESJustus-Liebig-Universität Gießen · DEBerlin-Brandenburger Centrum für Regenerative Therapien · DELawrence Berkeley National Laboratory · USLeibniz Institute of Freshwater Ecology and Inland Fisheries · DEMax Delbrück Center · DEMax Planck Institute for the Physics of Complex Systems · DEUniversity of Bern · CHUniversity of Vienna · AT
Funding
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1MNHGRI NIH HHS R01 HG003988
Abstract
Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole,
Indexed as
Regulatory Elements, TranscriptionalAdaptation, PhysiologicalAnimalsChromosome InversionDatasets as TopicFemaleFibroblast Growth Factor 9Gene Expression RegulationGenomeMiceMice, TransgenicMolesSex DifferentiationSteroid 17-alpha-HydroxylaseTandem Repeat SequencesTestosteroneFibroblast Growth Factor 9Steroid 17-alpha-HydroxylaseTestosterone
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