ArticleDevelopment (Cambridge, England)2020
Perturbation analysis of a multi-morphogen Turing reaction-diffusion stripe patterning system reveals key regulatory interactions.
Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Fundamental limits on symmetry breaking by Turing-like activator-inhibitor mechanisms.Development (Cambridge, England) · 2026Article
- Widespread biochemical reaction networks enable Turing patterns without imposed feedback.Nature communications · 2024Article
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction-Diffusion and Chemotaxis.Bulletin of mathematical biology · 2023Article
- Bat teeth illuminate the diversification of mammalian tooth classes.Nature communications · 2023Article
- Self-Organization and Genomic Causality in Models of Morphogenesis.Entropy (Basel, Switzerland) · 2023Review
- Article
- Modern perspectives on near-equilibrium analysis of Turing systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Review
- Systems for intricate patterning of the vertebrate anatomy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Computational biology: Turing's lessons in simplicity.Biophysical journal · 2021Review
- Bespoke Turing Systems.Bulletin of mathematical biology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Periodic patterning is widespread in development and can be modelled by reaction-diffusion (RD) processes. However, minimal two-component RD descriptions are vastly simpler than the multi-molecular events that actually occur and are often hard to relate to real interactions measured experimentally. Addressing these issues, we investigated the periodic striped patterning of the rugae (transverse ridges) in the mammalian oral palate, focusing on multiple previously implicated pathways: FGF, Hh, Wnt and BMP. For each, we experimentally identified spatial patterns of activity and distinct responses of the system to inhibition. Through numerical and analytical approaches, we were able to constrain substantially the number of network structures consistent with the data. Determination of the dynamics of pattern appearance further revealed its initiation by 'activators' FGF and Wnt, and 'inhibitor' Hh, whereas BMP and mesenchyme-specific-FGF signalling were incorporated once stripes were formed. This further limited the number of possible networks. Experimental constraint thus limited the number of possible minimal networks to 154, just 0.004% of the number of possible diffusion-driven instability networks. Together, these studies articulate the principles of multi-morphogen RD patterning and demonstrate the utility of perturbation analysis for constraining RD systems.This article has an associated 'The people behind the papers' interview.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.