Evidence map›Paper›PMID 33033097›Full record

ArticleBMJ open2020

Stroke incidence and subtypes in Aboriginal people in remote Australia: a healthcare network population-based study.

Anna H Balabanski, Kendall Goldsmith, Blake Giarola, David Buxton, Sally Castle, Katharine McBride, Stephen Brady, Amanda G Thrift, Judith Katzenellenbogen, Alex Brown and 4 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Anna H BalabanskiDepartment of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID 0000-0003-3209-3101
Kendall GoldsmithDepartment of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Blake GiarolaDepartment of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
David BuxtonDepartment of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Sally CastleAboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Katharine McBrideAboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Stephen BradyDepartment of Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.
Amanda G ThriftDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-8533-4170
Judith KatzenellenbogenSchool of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-5287-5819
Alex BrownAboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
James BurrowDepartment of Neurology, Royal Darwin Hospital, Casuarina, Northern Territory, Australia.
Geoffrey A DonnanDepartment of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, Victoria, Australia.
Simon KoblarStroke Research Programme, The University of Adelaide, Adelaide, South Australia, Australia.
Timothy J KleinigDepartment of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia timothy.kleinig@sa.gov.au.
Royal Adelaide Hospital · AUSouth Australian Health and Medical Research Institute · AUAlice Springs Hospital · AUMonash University · AURoyal Darwin Hospital · AURoyal Prince Alfred Hospital · AUThe Royal Melbourne Hospital · AUThe University of Adelaide · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to compare the incidence, subtypes and aetiology of stroke, and in-hospital death due to stroke, between Aboriginal and non-Aboriginal people in Central Australia, a remote region of Australia where a high proportion Aboriginal people reside (40% of the population). We hypothesised that the rates of stroke, particularly in younger adults, would be greater in the Aboriginal population, compared with the non-Aboriginal population; we aimed to elucidate causes for any identified disparities.

designA retrospective population-based study of patients hospitalised with stroke within a defined region from 1 January 2011 to 31 December 2014.

settingAlice Springs Hospital, the only neuroimaging-capable acute hospital in Central Australia, serving a network of 50 healthcare facilities covering 672 000 km

participants161 residents (63.4% Aboriginal) of the catchment area admitted to hospital with stroke. PRIMARY AND SECONDARY OUTCOME MEASURES: Rates of first-ever stroke, overall (all events) stroke and in-hospital death.

resultsOf 121 residents with first-ever stroke, 61% identified as Aboriginal. Median onset-age (54 years) was 17 years younger in Aboriginal patients (p<0.001), and age-standardised stroke incidence was threefold that of non-Aboriginal patients (153 vs 51 per 100 000, incidence rate ratio 3.0, 95% CI 2 to 4). The rate ratios for the overall rate of stroke (first-ever and recurrent) were similar. In Aboriginal patients aged <55 years, the incidence of ischaemic stroke was 14-fold greater (95% CI 4 to 45), and intracerebral haemorrhage 19-fold greater (95% CI 3 to 142) than in non-Aboriginal patients. Crude prevalence of diabetes mellitus (70.3% vs 34.0%, p<0.001) and hypercholesterolaemia (68.9% vs 51.1%, p=0.049) was greater, and age-standardised in-hospital deaths were fivefold greater (35 vs 7 per 100 000, 95% CI 2 to 11) in Aboriginal patients than in non-Aboriginal patients.

conclusionsStroke incidence (both subtypes) and in-hospital deaths for remote Aboriginal Australians are dramatically greater than in non-Aboriginal people, especially in patients aged <55 years.

Indexed as

Brain IschemiaStrokeAdolescentAdultAgedAustraliaDelivery of Health CareHospital MortalityHumansIncidenceMaleMiddle AgedRetrospective StudiesepidemiologyIndigenousintracerebral haemorrhageischaemic strokestroke

Identifiers

PMID33033097
PMCPMC7545633
OpenAlexW3092221370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.