ArticleAJNR. American journal of neuroradiology2020
Characterization of MR Imaging-Visible Perivascular Spaces in the White Matter of Healthy Adolescents at 3T.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Quantifying dilated perivascular spaces in children with sickle cell disease.Pediatric blood & cancer · 2024Trial
- Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.Annals of neurology · 2026Article
- Aging macaques bridge the translational gap in perivascular space biology.Scientific reports · 2026Article
- Genetic Architecture of Perivascular Space Morphology in the Pediatric Brain.bioRxiv : the preprint server for biology · 2026Article
- Aging macaques bridge the translational gap in perivascular space biology.bioRxiv : the preprint server for biology · 2026Article
- Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.Neurology international · 2025Review
- Review
- Biological Sex and Body Mass Index Influence the Longitudinal Evolution of Adolescent and Young Adult Magnetic Resonance Imaging-Visible Perivascular Spaces.Pediatric neurology · 2025Article
- Perivascular Space Burden in Children With Autism Spectrum Disorder Correlates With Neurodevelopmental Severity.Journal of magnetic resonance imaging : JMRI · 2025Article
- Association of Hypoxic-Ischemic Injury of the Brain With MRI-Derived Glymphatic Function Parameters in Neonates.Korean journal of radiology · 2025Article
- Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis.Epilepsia · 2025Observational
- Visualization of perivascular spaces in the human brain with 5-T magnetic resonance imaging.BMC neuroscience · 2025Article
- Article
- Assessing glymphatic-associated fluid dynamics in psychiatric disorders: evidence from neuroimaging - a review.Psychoradiology · 2025Review
- Article
- Beyond the cerebellum: perivascular space burden in spinocerebellar ataxia type 3 extends to multiple brain regions.Brain communications · 2025Article
- The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players.JAMA network open · 2024Article
- Perivascular Space Burden and Cerebrospinal Fluid Biomarkers in US Veterans With Blast-Related Mild Traumatic Brain Injury.Journal of neurotrauma · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
background and purposePerivascular spaces play a role in cerebral waste removal and neuroinflammation. Our aim was to provide data regarding the burden of MR imaging-visible perivascular spaces in white matter in healthy adolescents using an automated segmentation method and to establish relationships between common demographic characteristics and perivascular space burden. MATERIALS AND
methodsOne hundred eighteen 12- to 21-year-old subjects underwent T1- and T2-weighted 3T MR imaging as part of the National Consortium on Alcohol and Neurodevelopment in Adolescence. Perivascular spaces were identified in WM on T2-weighted imaging using a local heterogeneity approach coupled with morphologic constraints, and their spatial distribution and geometric characteristics were assessed.
resultsMR imaging-visible perivascular spaces were identified in all subjects (range, 16-287). Males had a significantly higher number of perivascular spaces than females: males, mean, 98.4 ± 50.5, versus females, 70.7 ± 36.1, (
conclusionsDespite a wide range of burden, perivascular spaces are present in all healthy adolescents. Perivascular space burden is higher in adolescent males than in females, regardless of age and pubertal status. In this population, perivascular spaces are highly symmetric. Although widely reported as a feature of the aging brain, awareness of the presence of perivascular spaces in a cohort of healthy adolescents provides the foundation for further research regarding the role of these structural variants in health and disease.
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Registered trials
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