Evidence map›Paper›PMID 33033018›Full record

ArticleBMJ open2020

The Seattle Flu Study: a multiarm community-based prospective study protocol for assessing influenza prevalence, transmission and genomic epidemiology.

Helen Y Chu, Michael Boeckh, Janet A Englund, Michael Famulare, Barry Lutz, Deborah A Nickerson, Mark Rieder, Lea M Starita, Amanda Adler, Elisabeth Brandstetter and 16 more

Abstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Helen Y ChuDepartment of Medicine, University of Washington, Seattle, Washington, USA helenchu@uw.edu.
Michael BoeckhVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Janet A EnglundDivision of Pediatric Infectious Diseases, Allergy, and Rheumatology, University of Washington, Seattle, Washington, USA.
Michael FamulareInstitute for Disease Modeling, Bellevue, Washington, USA.
Barry LutzBioengineering, University of Washington, Seattle, Washington, USA.
Deborah A NickersonGenome Sciences, University of Washington, Seattle, Washington, USA.
Mark RiederBrotman Baty Institute, University of Washington, Seattle, Washington, USA.
Lea M StaritaGenome Sciences, University of Washington, Seattle, Washington, USA.
Amanda AdlerSeattle Children's Research Institute, Seattle, Washington, USA.
Elisabeth BrandstetterDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Chris D FrazerDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Peter D HanBrotman Baty Institute, University of Washington, Seattle, Washington, USA.
Reena K GulatiCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
James HadfieldDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Michael JacksonKaiser Permanente, Oakland, California, USA.
Anahita KiavandDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Louise E KimballVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Kirsten LacombeSeattle Children's Research Institute, Seattle, Washington, USA.
Kira NewmanDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Thomas R SibleyVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Jennifer K LogueMedicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-7889-8960
Victoria Rachel LyonFamily Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-5669-1099
Caitlin R WolfDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Monica Zigman SuchslandUniversity of Washington, Seattle, Washington, USA.ORCID 0000-0001-7007-6973
Jay ShendureGenome Sciences, University of Washington, Seattle, Washington, USA.
Trevor BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfluenza epidemics and pandemics cause significant morbidity and mortality. An effective response to a potential pandemic requires the infrastructure to rapidly detect, characterise, and potentially contain new and emerging influenza strains at both an individual and population level. The objective of this study is to use data gathered simultaneously from community and hospital sites to develop a model of how influenza enters and spreads in a population. METHODS AND ANALYSIS: Starting in the 2018-2019 season, we have been enrolling individuals with acute respiratory illness from community sites throughout the Seattle metropolitan area, including clinics, childcare facilities, Seattle-Tacoma International Airport, workplaces, college campuses and homeless shelters. At these sites, we collect clinical data and mid-nasal swabs from individuals with at least two acute respiratory symptoms. Additionally, we collect residual nasal swabs and data from individuals who seek care for respiratory symptoms at four regional hospitals. Samples are tested using a multiplex molecular assay, and influenza whole genome sequencing is performed for samples with influenza detected. Geospatial mapping and computational modelling platforms are in development to characterise the regional spread of influenza and other respiratory pathogens. ETHICS AND DISSEMINATION: The study was approved by the University of Washington's Institutional Review Board (STUDY00006181). Results will be disseminated through talks at conferences, peer-reviewed publications and on the study website (www.seattleflu.org).

Indexed as

Influenza, HumanGenomicsHumansPrevalenceProspective StudiesSeasonsinfluenzaprotocolrespiratory infectionsurveillancevirology

Identifiers

PMID33033018
PMCPMC7542952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.