ArticleBMJ open2020
Can extranodal tumour deposits be diagnosed on MRI? Protocol for a multicentre clinical trial (the COMET trial).
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03303547 (Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Prognostic Impact of Imaging Detected Tumor Deposits in Rectal Cancer: A Systematic Review and Meta-analysis.Annals of surgical oncology · 2026Pooled it
- Tumor deposits on MRI in rectal cancer-detection and differentiation from lymph nodes with histopathological correlation.European radiology · 2026Article
- MRI to guide clinical management of rectal cancer: updated consensus recommendations from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR)-PART I primary staging.European radiology · 2026Article
- Development and validation: a whole-tumor histogram model based on intravoxel incoherent motion diffusion-weighted imaging for diagnosing tumor deposits in rectal cancer.Abdominal radiology (New York) · 2026Article
- MRI-Based Differentiation of Tumor Deposits and Lymph Node Metastases in Rectal Cancer: A Systematic Review of Diagnostic Performance.Journal of clinical medicine · 2026Review
- D3 lymph node dissection in right-sided colon cancer: routine requirement or selective application?Journal of gastrointestinal oncology · 2025Article
- Development and evaluation of the mrTE scoring system for MRI-detected tumor deposits and extramural venous invasion in rectal cancer.Abdominal radiology (New York) · 2025Article
- Evaluation of MRI characterisation of histopathologically matched lymph nodes and other mesorectal nodal structures in rectal cancer.European radiology · 2025Article
- Radiomics analysis of dual-layer spectral-detector CT-derived iodine maps for predicting tumor deposits in colorectal cancer.European radiology · 2025Article
- Tumour deposit count is an independent prognostic factor in colorectal cancer-a population-based cohort study.The British journal of surgery · 2024Article
- The Role of Predictive and Prognostic MRI-Based Biomarkers in the Era of Total Neoadjuvant Treatment in Rectal Cancer.Cancers · 2024Review
- MRI-detected tumor deposits in cT3 and cT4 rectal cancer following neoadjuvant chemoradiotherapy.European radiology · 2024Article
- Clinical and Pathologic Predictors of Tumor Deposits in Colorectal Cancer.Journal of gastrointestinal cancer · 2024Article
- Article
- MRI-based multiregional radiomics for preoperative prediction of tumor deposit and prognosis in resectable rectal cancer: a bicenter study.European radiology · 2023Article
- An MRI-based scoring system for pretreatment risk stratification in locally advanced rectal cancer.British journal of cancer · 2023Observational
- Distinguishing mesorectal tumor deposits from metastatic lymph nodes by using diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in rectal cancer.European radiology · 2023Article
- [Interpretation of Rectal MRI after Neoadjuvant Treatment in Patients with Rectal Cancer].Journal of the Korean Society of Radiology · 2023Review
- Magnetic resonance imaging radiomics modeling predicts tumor deposits and prognosis in stage T3 lymph node positive rectal cancer.Abdominal radiology (New York) · 2023Article
- Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes - a pre-clinical study.The British journal of radiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTumour deposits (TDs) are a poor prognostic marker when seen on pathology, and are worse than lymph node metastases (LNMs). They are now being reported on MRI as discontinuous nodules of extramural venous invasion but this diagnosis has not been validated and it is unclear how it correlates with the diagnosis of TDs on pathology. METHODS AND ANALYSIS: This is a prospective interventional clinical trial which aims to directly map the location of TDs on MRI and correlate what is seen on MRI with the pathology findings at each location. All patients with rectal cancer undergoing resectional surgery are eligible (including those undergoing preoperative therapy). The primary outcome is the prevalence of TDs seen on pathology. Secondary outcomes are to assess radiological and pathological interobserver agreement, assess the effect of TDs on prognosis and carry out exploratory work looking at differences between TDs and LNMs. The estimated sample size is 100 to detect a twofold increase in the pathological diagnosis of TD when MRI mapping is used. ETHICS AND DISSEMINATION: Ethical approval has been granted from the South Central-Hampshire B Research and Ethics Committee (IRAS 217627). The study will be carried out under standard operative procedures within the Royal Marsden Hospital. TRIAL REGISTRATION NUMBER: NCT03303547.
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