ArticleAnnals of the rheumatic diseases2021
Burden and trajectory of multimorbidity in rheumatoid arthritis: a matched cohort study from 2006 to 2015.
Article in Annals of the rheumatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 64 citations in OpenAlex.
- Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis.Arthritis care & research · 2026Article
- Comorbidity Profiles at Diagnosis in Rheumatoid Arthritis Versus Psoriatic Arthritis: A Nationwide Polish Claims-Based Study.Journal of clinical medicine · 2026Article
- The evolving comorbidity landscape of rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Multimorbidity and risk of infection in patients with rheumatoid arthritis: Population-based case-control study.Seminars in arthritis and rheumatism · 2026Article
- Heterogeneity of Rheumatoid Arthritis-Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes.Arthritis care & research · 2026Article
- Difficult to manage axial spondyloarthritis patients have high burden of pain-related comorbidities and adverse long-term outcome.Arthritis research & therapy · 2026Article
- MCCs in adults with autoimmune and inflammatory rheumatic diseases: evidence to date and future directions.Therapeutic advances in musculoskeletal disease · 2026Review
- Differences in Cause-Specific Mortality in Patients With Rheumatoid Arthritis by Sex and Seropositivity.The Journal of rheumatology · 2025Article
- Ageism in Rheumatology: The Health Care Professional's Perspective.Arthritis care & research · 2025Article
- Article
- Predictive value of insulin resistance metabolic score for cardiovascular disease in Chinese arthritis patients: a prospective cohort study.Rheumatology (Oxford, England) · 2025Article
- Risk of Incident Heart Failure and Heart Failure Subtypes in Patients With Rheumatoid Arthritis.Arthritis care & research · 2025Article
- Unveiling health inequalities and frontier gaps in elderly-onset rheumatoid arthritis: evolving impact of smoking and future challenges.Frontiers in medicine · 2025Article
- Understanding the multiple dimensions of ageing: 5Ms for the rheumatologist.The Lancet. Rheumatology · 2024Review
- Development and validation of a rheumatoid arthritis case definition: a machine learning approach using data from primary care electronic medical records.BMC medical informatics and decision making · 2024Article
- Multimorbidity in systemic lupus erythematosus in a population-based cohort: the Lupus Midwest Network.Rheumatology (Oxford, England) · 2024Article
- Observational
- Disparities in multimorbidity and comorbidities in rheumatoid arthritis by sex across the lifespan.Rheumatology (Oxford, England) · 2024Article
- Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis.Annals of the rheumatic diseases · 2024Article
- Multiple morbidities are associated with serious infections in patients with rheumatoid arthritis.Seminars in arthritis and rheumatism · 2024Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesTo compare the onset and trajectory of multimorbidity between individuals with and without rheumatoid arthritis (RA).
methodsA matched, retrospective cohort study was completed in a large, US commercial insurance database (MarketScan) from 2006 to 2015. Using validated algorithms, patients with RA (overall and incident) were age-matched and sex-matched to patients without RA. Diagnostic codes for 44 preidentified chronic conditions were selected to determine the presence (≥2 conditions) and burden (count) of multimorbidity. Cross-sectional comparisons were completed using the overall RA cohort and conditional logistic and negative binomial regression models. Trajectories of multimorbidity were assessed within the incident RA subcohort using generalised estimating equations.
resultsThe overall cohort (n=277 782) and incident subcohort (n=61 124) were female predominant (76.5%, 74.1%) with a mean age of 55.6 years and 54.5 years, respectively. The cross-sectional prevalence (OR 2.29, 95% CI 2.25 to 2.34) and burden (ratio of conditions 1.68, 95% CI 1.66 to 1.70) of multimorbidity were significantly higher in RA than non-RA in the overall cohort. Within the incident RA cohort, patients with RA had more chronic conditions than non-RA (β 1.13, 95% CI 1.10 to 1.17), and the rate of accruing chronic conditions was significantly higher in RA compared with non-RA (RA × follow-up year, β 0.21, 95% CI 0.20 to 0.21, p<0.001). Results were similar when including the pre-RA period and in several sensitivity analyses.
conclusionsMultimorbidity is highly prevalent in RA and progresses more rapidly in patients with RA than in patients without RA during and immediately following RA onset. Therefore, multimorbidity should be aggressively identified and targeted early in the RA disease course.
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