ArticleBMC musculoskeletal disorders2020
Mortality among persons experiencing musculoskeletal pain: a prospective study among Danish men and women.
Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Risk of cancer incidence and mortality in patients with chronic pain: A systematic review and meta-analysis.Cancer metastasis reviews · 2026Pooled it
- Association of musculoskeletal pain with incidence and recurrence of cardiovascular disease: a longitudinal cohort in China.BMC public health · 2026Article
- Joint influence of lifestyle and chronic musculoskeletal pain on all-cause mortality: the HUNT Study.BMJ open sport & exercise medicine · 2026Article
- Chronic pain and mortality risk among middle-age and older Japanese: the Shika town cohort study.Pain reports · 2025Article
- Self-reported pain is associated with a poorer long-term prognosis in patients with myocardial infarction: A SWEDEHEART study.International journal of cardiology. Heart & vasculature · 2025Article
- Mediating Effect of IADL and Depression in the Relationship Between Ability to Perform Movements and Death Preparation in Elderly with Osteoarthritis or Rheumatoid Arthritis.Healthcare (Basel, Switzerland) · 2025Article
- Application of GUHA data mining method in cohort data to explore paths associated with premature death: a 29-year follow-up study.BMC medical research methodology · 2025Article
- Pain in the body, harm to the heart: advances in research on the impact of chronic pain on cardiovascular diseases.Frontiers in cardiovascular medicine · 2025Review
- What Predicts a Longer Period of Pain in Patients Referred to an Interdisciplinary Center for Pain Care?International journal of environmental research and public health · 2024Article
- Chronic widespread pain and cause of death: a 25-year follow-up study.Pain reports · 2024Article
- High Self-Reported Levels of Pain 1 Year After a Myocardial Infarction Are Related to Long-Term All-Cause Mortality: A SWEDEHEART Study Including 18 376 Patients.Journal of the American Heart Association · 2023Article
- Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.International journal of molecular sciences · 2023Review
- Chronic pain is a risk factor for incident Alzheimer's disease: a nationwide propensity-matched cohort using administrative data.Frontiers in aging neuroscience · 2023Article
- Association of chronic musculoskeletal pain with mortality among UK adults: A population-based cohort study with mediation analysis.EClinicalMedicine · 2021Article
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundMusculoskeletal (MSK) pain affects many people worldwide and has a great impact on general health and quality of life. However, the relationship between MSK pain and mortality is not clear. This study aimed to investigate all-cause and cause-specific mortality in relation to self-reported MSK pain within the last 14 days, including spread of pain and pain intensity.
methodsThis prospective cohort study included a representative cohort of 4806 men and women aged 16+ years, who participated in a Danish MSK survey 1990-1991. The survey comprised questions on MSK pain, including spread of pain and pain intensity. These data were linked with the Danish Register of Causes of Death to obtain information on cause of death. Mean follow-up was 19.1 years. Cox regression analyses were performed with adjustment for potential confounders.
resultsIn the study population (mean age 44.5 years; 47.9% men), 41.0% had experienced MSK pain within the last 14 days and 1372 persons died during follow-up. For both sexes, increased all-cause mortality with higher spread and intensity of MSK pain was observed; a high risk was observed especially for men with strong pain (HR = 1.66; 95% CI:1.09-2.53) and women with widespread pain (HR = 1.49; 95% CI:1.16-1.92). MSK pain within last 14 days yielded c-statistics of 0.544 and 0.887 with age added. Moreover, persons with strong MSK pain had an increased cardiovascular mortality, persons with moderate pain and pain in two areas had an increased risk of cancer mortality, and persons with widespread pain had an increased risk of respiratory mortality.
conclusionsOverall, persons experiencing MSK pain had a higher risk of mortality. The increased mortality was not accounted for by potential confounders. However, when evaluating these results, it is important to take the possibility of unmeasured confounders into account as we had no information on e.g. BMI etc. SIGNIFICANCE: The present study provides new insights into the long-term consequences of MSK pain. However, the discriminatory accuracy of MSK pain was low, which indicates that this information cannot stand alone when predicting mortality risk.
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