Evidence map›Paper›PMID 33032489›Full record

Observational studyStroke2020

Natural History of Hemodynamics in Vertebrobasilar Disease: Temporal Changes in the VERiTAS Study Cohort.

Sepideh Amin-Hanjani, Alfred P See, Xinjian Du, Linda Rose-Finnell, Dilip K Pandey, Yi-Fan Chen, Mitchell S V Elkind, Gregory J Zipfel, David S Liebeskind, Frank L Silver and 5 more

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00590980 (The Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00590980 completednot on this map

The Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Study

TypeobservationalSponsorUniversity of Illinois at ChicagoRan2008 to 2014Enrolled82ConditionsVertebrobasilar Insufficiency, Ischemic Attack, Transient, Cerebrovascular Disorder, Brain Ischemia
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Sepideh Amin-HanjaniDepartment of Neurosurgery (S.A.-H., A.P.S., X.D., L.R.-F., F.T.C.), University of Illinois at Chicago.
Alfred P SeeDepartment of Neurosurgery (S.A.-H., A.P.S., X.D., L.R.-F., F.T.C.), University of Illinois at Chicago.
Xinjian DuDepartment of Neurosurgery (S.A.-H., A.P.S., X.D., L.R.-F., F.T.C.), University of Illinois at Chicago.
Linda Rose-FinnellDepartment of Neurosurgery (S.A.-H., A.P.S., X.D., L.R.-F., F.T.C.), University of Illinois at Chicago.
Dilip K PandeyDepartment of Neurology and Rehabilitation (D.K.P.), University of Illinois at Chicago.
Yi-Fan ChenCenter for Clinical and Translational Science (Y.-F.C.), University of Illinois at Chicago.
Mitchell S V ElkindDepartments of Neurology and Epidemiology, Columbia University, New York (M.S.V.E.).
Gregory J ZipfelDepartments of Neurosurgery and Neurology, Washington University in St Louis, MO (G.J.Z.).
David S LiebeskindDepartment of Neurology, UCLA (University of California, Los Angeles) (D.S.L.).
Frank L SilverDivision of Neurology, Department of Medicine, University of Toronto, ON, Canada (F.L.S.).
Scott E KasnerDepartment of Neurology, University of Pennsylvania, Philadelphia (S.E.K.).
Philip B GorelickDepartment of Translational Neuroscience, Michigan State University College of Human Medicine, Grand Rapids (P.B.G.).
Fady T CharbelDepartment of Neurosurgery (S.A.-H., A.P.S., X.D., L.R.-F., F.T.C.), University of Illinois at Chicago.
Colin P DerdeynDepartment of Radiology, University of Iowa Hospitals and Clinics, Iowa City (C.P.D.).
VERiTAS Study Group
University of Illinois Chicago · USGrand Rapids Community College · USMitchell College · USUniversity of California, Los Angeles · USUniversity of Iowa Hospitals and Clinics · USUniversity of Pennsylvania · USUniversity of Toronto · CAWashington University in St. Louis · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and StrokeR01NS059745 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AMIN-HANJANI, SEPIDEH · 2008 to 2012
$2.1M
NCATS NIH HHS UL1 TR002003NINDS NIH HHS R01 NS059745
6 · The paper itself

Abstract

background and purposeThe role of regional hypoperfusion as a contributor to stroke risk in atherosclerotic vertebrobasilar disease has recently been confirmed by the observational VERiTAS (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke) Study. We examined the stability of hemodynamic status over time and its relationship to stroke risk in patients from this prospective cohort.

methodsVERiTAS enrolled patients with recently symptomatic ≥50% atherosclerotic stenosis/occlusion of vertebral and/or basilar arteries. Large vessel flow in the vertebrobasilar territory was assessed using quantitative magnetic resonance angiography, and patients were designated as low or normal flow based on distal territory regional flow, incorporating collateral capacity. Patients underwent standard medical management and follow-up for primary outcome event of vertebrobasilar territory stroke. Quantitative magnetic resonance angiography imaging was repeated at 6, 12, and 24 months. Flow status over time was examined relative to baseline and relative to subsequent stroke risk using a cause-specific proportional hazard model, with flow status treated as a time-varying covariate. Mean blood pressure was examined to assess for association with changes in flow status.

resultsOver 19±8 months of follow-up, 132 follow-up quantitative magnetic resonance angiography studies were performed in 58 of the 72 enrolled patients. Of the 13 patients with serial imaging who had low flow at baseline, 7 (54%) had improvement to normal flow at the last follow-up. Of the 45 patients who had normal flow at baseline, 3 (7%) converted to low flow at the last follow-up. The mean blood pressure did not differ in patients with or without changes in flow status. The time-varying flow status remained a strong predictor of subsequent stroke (hazard ratio, 10.3 [95% CI, 2.2-48.7]).

conclusionsThere is potential both for improvement and worsening of hemodynamics in patients with atherosclerotic vertebrobasilar disease. Flow status, both at baseline and over time, is a risk factor for subsequent stroke, thus serving as an important prognostic marker. Registration: URL: https://clinicaltrials.gov. Unique identifier: NCT00590980.

Indexed as

Cerebrovascular CirculationHemodynamicsAgedCohort StudiesFemaleHumansIntracranial ArteriosclerosisIschemic StrokeMagnetic Resonance AngiographyMaleMiddle AgedProportional Hazards ModelsProspective StudiesVertebrobasilar Insufficiencyatherosclerosisblood pressurehemodynamicsischemic attack, transientmagnetic resonance angiographystrokevertebrobasilar insufficiency

Identifiers

PMID33032489
PMCPMC7606530
OpenAlexW3092258655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.