ArticleEuropean journal of neurology2021
Functional connectivity and topology in patients with restless legs syndrome: a case-control resting-state functional magnetic resonance imaging study.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Polysomnographic nighttime features of Restless Legs Syndrome: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Restless legs syndrome and periodic limb movements of sleep - the relationship with stroke and other cerebrovascular disease.Nature reviews. Neurology · 2026Review
- Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Restless Legs Syndrome and Impulsive Decision-Making: Impact of Symptom Severity, Chronotype and Interoception.Movement disorders clinical practice · 2025Article
- Restless legs syndrome: abbreviated guidelines by the German sleep society and the German neurological society.Neurological research and practice · 2024Article
- A Comparative Investigation of Functional Connectivity Utilizing Electroencephalography in Insomnia Patients with and without Restless Leg SyndromeClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- From brain to spinal cord: neuromodulation by direct current stimulation and its promising effects as a treatment option for restless legs syndrome.Frontiers in neurology · 2024Review
- Reduced Interoception Abilities in Patients with Restless Legs Syndrome.Movement disorders clinical practice · 2023Article
- Neuroanatomy and Functional Connectivity in Patients with Parkinson's Disease with or without Restless Legs Syndrome.Neurology and therapy · 2022Article
- The relationship between sleep disorders, anxiety, depression, and cognitive function with restless legs syndrome (RLS) in the elderly.Sleep & breathing = Schlaf & Atmung · 2022Article
- Restless legs syndrome: Over 50 years of European contribution.Journal of sleep research · 2022Review
- Advanced network neuroimaging as an approach to unravel the pathophysiology of restless legs syndrome.Sleep · 2022Article
- Alterations of Functional Connectivity in Patients With Restless Legs Syndrome.Journal of clinical neurology (Seoul, Korea) · 2022Review
- Restless Legs Syndrome: Known Knowns and Known Unknowns.Brain sciences · 2022Article
- Myoclonus and other jerky movement disorders.Clinical neurophysiology practice · 2022Review
- Analysis of Brain Activity Changes in Patients with Parkinson's Disease Based on Resting-State Functional Magnetic Resonance Imaging.Journal of healthcare engineering · 2022Article
- Correlation between vitamin D and poor sleep status in restless legs syndrome.Frontiers in endocrinology · 2022Article
- Restless legs syndrome.Nature reviews. Disease primers · 2021Review
- Cognitive profile in Restless Legs Syndrome: A signal-to-noise ratio account.Current research in neurobiology · 2021Review
- Prevalence of Restless Leg Syndrome, Associated Variables and Impact on Sleep Quality in a Cohort of Patients with Neuropsychiatric Disorders.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeFunctional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients.
methodsEighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha-2-delta ligands as mono- or polytherapy combined with dopaminergic medication, n = 10), and 82 individually age- and gender-matched healthy controls were studied with resting-state functional magnetic resonance imaging. Connectivity of 12 resting-state networks was investigated with independent component analysis, and network topology was studied with graph methods among 410 brain regions.
resultsPatients with restless legs syndrome showed significantly higher connectivity within salience (p = 0.029), executive (p = 0.001), and cerebellar (p = 0.041) networks, as well as significantly lower (p < 0.05) cerebello-frontal communication compared to controls. In addition, they had a significantly higher (p < 0.05) clustering coefficient and local efficiency in motor and frontal regions; lower clustering coefficient in the central sulcus; and lower local efficiency in the central opercular cortex, temporal, parieto-occipital, cuneus, and occipital regions compared to controls. Untreated patients had significantly lower (p < 0.05) cerebello-parietal communication compared to healthy controls. Connectivity between the thalamus and frontal regions was significantly increased (p < 0.05) in patients on dopaminergic medication compared to untreated patients and controls.
conclusionsNetworks with higher intranetwork connectivity (i.e., salience, executive, cerebellar) and lower cerebello-frontal connectivity in the restless legs syndrome patients, as well as lower cerebello-parietal connectivity in untreated patients, correspond to regions associated with attention, response inhibitory control, and processing of sensory information. Intact cerebello-parietal communication and increased thalamic connectivity to the prefrontal regions in patients on dopaminergic medication suggests a treatment effect on thalamus.
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