ArticleAmerican journal of perinatology2021
Effect of a Nonoptimal Cervicovaginal Microbiota and Psychosocial Stress on Recurrent Spontaneous Preterm Birth.
Article in American journal of perinatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- VISTA: a classifier for metagenomic subspecies and community state typing of the vaginal microbiome.Microbiology resource announcements · 2026Article
- The vaginal microbiota, symptoms, and local immune correlates in transmasculine individuals using sustained testosterone therapy.Cell reports · 2025Article
- Affective symptoms in pregnancy are associated with the vaginal microbiome.Journal of affective disorders · 2025Article
- Characterization of vaginal microbiota across female reproductive phases.Frontiers in microbiology · 2025Article
- Diet influences community dynamics following vaginal group B streptococcus colonization.Microbiology spectrum · 2024Article
- Cervicovaginal Microbial-Immune State and Group B Streptococcus Colonization in Pregnancy.American journal of perinatology · 2024Article
- Affective Symptoms in Pregnancy are Associated with the Vaginal Microbiome.bioRxiv : the preprint server for biology · 2024Article
- The role of neighborhood deprivation in the cervicovaginal microbiota.American journal of obstetrics & gynecology MFM · 2024Article
- Impact of exposure to air pollution on cervicovaginal microbial communities.Environmental research · 2023Article
- Interactions between perceived stress and microbial-host immune components: two demographically and geographically distinct pregnancy cohorts.Translational psychiatry · 2023Article
- Racism and perinatal health inequities research: where we have been and where we should go.American journal of obstetrics and gynecology · 2022Article
- Vaginal Microbiome Composition in Early Pregnancy and Risk of Spontaneous Preterm and Early Term Birth Among African American Women.Frontiers in cellular and infection microbiology · 2021Article
- Relationship Between Vaginal Microbiome and Preterm Birth During Pregnancy: In Different Ethnic Populations.Women's health reports (New Rochelle, N.Y.)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveWhile select cervicovaginal microbiota and psychosocial factors have been associated with spontaneous preterm birth, their effect on the risk of recurrence remains unclear. It is also unknown whether psychosocial factors amplify underlying biologic risk. This study sought to determine the effect of nonoptimal cervicovaginal microbiota and perceived stress on the risk of recurrent spontaneous preterm birth. STUDY
designThis was a secondary analysis of a prospective pregnancy cohort,
resultsAmong the 181 women with prior spontaneous preterm birth, 45 (24.9%) had high perceived stress. We did not detect a significant association between high stress and recurrent spontaneous preterm birth (adjusted odds ratio [aOR] 1.67, 95% confidence interval [CI]: 0.73-3.85). Among the 74 women with prior spontaneous preterm birth and cervicovaginal microbiota analyzed, 29 (39.2%) had CST IV; this proportion differed significantly among women with recurrent spontaneous preterm birth (51.4%) compared with women with term birth (28.2%) (
conclusionAmong a predominantly non-Hispanic Black cohort of women with a prior spontaneous preterm birth, a nonoptimal cervicovaginal microbiota is associated with increased odds of recurrent spontaneous preterm birth. Adjustment for perceived stress may amplify associations between CST IV and recurrent spontaneous preterm birth. Identification of modifiable social or behavioral factors may unveil novel nonpharmacologic interventions to decrease recurrent spontaneous preterm birth among women with underlying biologic risk. KEY POINTS: · CST IV, a nonoptimal microbiota, is associated with increased odds of recurrent spontaneous preterm birth.. · Adjustment for perceived stress amplified associations between CST IV and recurrent spontaneous preterm birth.. · Identification of modifiable psychosocial factors may unveil novel nonpharmacologic interventions to decrease recurrent preterm birth..
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