ReviewCurrent opinion in chemical biology2020
Rewiring yeast metabolism to synthesize products beyond ethanol.
Review in Current opinion in chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Toward engineered microbial chassis for growth-production balancing.Synthetic and systems biotechnology · 2027Review
- Article
- Yeast Stress Response to Synthetic Constructs.ACS synthetic biology · 2026Review
- In vivo pathway optimization in yeast via loxpsym-mediated shuffling of upstream activating sequences.Nucleic acids research · 2025Article
- Application of Microbial Fermentation in Caffeine Degradation and Flavor Modulation of Coffee Beans.Foods (Basel, Switzerland) · 2025Review
- Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast.Nature communications · 2025Article
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.Applied microbiology and biotechnology · 2025Review
- Endogenous ethanol production in health and disease.Nature reviews. Gastroenterology & hepatology · 2024Review
- Optimizing the Conditions of Pretreatment and Enzymatic Hydrolysis of Sugarcane Bagasse for Bioethanol Production.ACS omega · 2024Article
- Genome engineering of Kluyveromyces marxianus for high D-( -)-lactic acid production under low pH conditions.Applied microbiology and biotechnology · 2023Article
- Gaining access to acetyl-CoA by peroxisomal surface display.Synthetic and systems biotechnology · 2023Article
- Metabolic Engineering ofJournal of fungi (Basel, Switzerland) · 2023Article
- Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production.Biotechnology for biofuels and bioproducts · 2023Article
- Rewiring regulation on respiro-fermentative metabolism relieved Crabtree effects inSynthetic and systems biotechnology · 2022Article
- Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals.Engineering microbiology · 2022Review
- The multiple effects of REG1 deletion and SNF1 overexpression improved the production of S-adenosyl-L-methionine in Saccharomyces cerevisiae.Microbial cell factories · 2022Article
- Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β-alanine metabolism.Microbial biotechnology · 2022Article
- Comparative functional genomics identifies an iron-limited bottleneck in aSynthetic and systems biotechnology · 2022Article
- Combinatorial library design for improving isobutanol production inFrontiers in bioengineering and biotechnology · 2022Article
- β-Ionone: Its Occurrence and Biological Function and Metabolic Engineering.Plants (Basel, Switzerland) · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Saccharomyces cerevisiae, Baker's yeast, is the industrial workhorse for producing ethanol and the subject of substantial metabolic engineering research in both industry and academia. S. cerevisiae has been used to demonstrate production of a wide range of chemical products from glucose. However, in many cases, the demonstrations report titers and yields that fall below thresholds for industrial feasibility. Ethanol synthesis is a central part of S. cerevisiae metabolism, and redirecting flux to other products remains a barrier to industrialize strains for producing other molecules. Removing ethanol producing pathways leads to poor fitness, such as impaired growth on glucose. Here, we review metabolic engineering efforts aimed at restoring growth in non-ethanol producing strains with emphasis on relieving glucose repression associated with the Crabtree effect and rewiring metabolism to provide access to critical cellular building blocks. Substantial progress has been made in the past decade, but many opportunities for improvement remain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.