Evidence map›Paper›PMID 33032233›Full record

ArticleAtherosclerosis2020

Maternal exposure to soy diet reduces atheroma in hyperlipidemic F1 offspring mice by promoting macrophage and T cell anti-inflammatory responses.

Ramona L Burris, Sarah C Vick, Branimir Popovic, Pamelia E Fraungruber, Shanmugam Nagarajan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ramona L BurrisArkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Sarah C VickDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Branimir PopovicDepartment of Pathology, Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Pamelia E FraungruberDepartment of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA.
Shanmugam NagarajanArkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Department of Pathology, Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA. Electronic address: shannag@med.unc.edu.
University of North Carolina Health Care · USArkansas Children's Nutrition Center · USUniversity of Arkansas for Medical Sciences · USUniversity of Pittsburgh · US

Funding

Role of Fc gamma receptors in atherosclerosisR01HL086674 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAGARAJAN, SHANMUGAM · 2008 to 2012
$1.8M
The Impact of Fc gamma Receptor Signaling on Lupus-Induced AtherosclerosisR01HL130126 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, SHANMUGAM · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL086674NHLBI NIH HHS R01 HL130126
6 · The paper itself

Abstract

BACKGROUND AND

aimsMaternal hypercholesterolemia has been implicated in earlier onset of atherosclerotic lesions in neonatal offspring. In this study, we investigated whether maternal exposure to soy protein isolate (SPI) diet attenuated the progression of atherosclerosis in F1 offspring.

methodPregnant apolipoprotein E knockout (Apoe

resultsAtherosclerotic lesions in the aortic sinuses were reduced in SPI-offspring compared with CAS-offspring. Total serum cholesterol levels in CAS-offspring or dams were comparable to levels in their SPI-counterparts, suggesting that alternative mechanisms contributed to the athero-protective effect of maternal SPI diet. Aortic VCAM-1, MCP-1, and TNF-α mRNA and protein expression, and expression of macrophage pro-inflammatory cytokines was reduced in SPI-offspring. Interestingly, CD4

conclusionsOur findings demonstrate that gestational and lactational soy diet exposure inhibits susceptibility to atherosclerotic lesion formation by promoting anti-inflammatory responses by macrophages and T cells.

Indexed as

Maternal ExposurePlaque, AtheroscleroticAdultAnimalsAnti-Inflammatory AgentsDietFemaleHumansMacrophagesMicePregnancyAnti-Inflammatory AgentsAtherosclerosisGestationInflammationMaternal hypercholesterolemiaSoy protein

Identifiers

PMID33032233
PMCPMC7655711
OpenAlexW3088199573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.