Evidence map›Paper›PMID 33032142›Full record

ReviewCurrent opinion in microbiology2020

Entamoeba stage conversion: progress and new insights.

Dipak Manna, Gretchen M Ehrenkaufer, Daniela Lozano-Amado, Upinder Singh

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. First Molecular Identification ofVeterinary sciences · 2025
    Article
  5. Article
  6. Article
  7. The macrophage polarization inFrontiers in immunology · 2024
    Article
  8. Amoebae: beyond pathogens- exploring their benefits and future potential.Frontiers in cellular and infection microbiology · 2024
    Review
  9. Review
  10. Review
  11. Giant cells: multiple cells unite to survive.Frontiers in cellular and infection microbiology · 2023
    Review
  12. Article
  13. Furanocoumarins fromMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dipak MannaDivision of Infectious Diseases, Stanford University School of Medicine, United States.
Gretchen M EhrenkauferDivision of Infectious Diseases, Stanford University School of Medicine, United States.
Daniela Lozano-AmadoDivision of Infectious Diseases, Stanford University School of Medicine, United States.
Upinder SinghDivision of Infectious Diseases, Stanford University School of Medicine, United States; Department of Microbiology and Immunology, Stanford University School of Medicine, United States. Electronic address: usingh@stanford.edu.

Funding

Characterization of encystation pathways in Entamoeba histolyticaR21AI150957 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2020 to 2021
$447k
Transcription factor control of Entamoeba developmentR21AI119893 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2015 to 2016
$435k
High throughput screening to identify compounds against Entamoeba cystsR21AI123594 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2016 to 2017
$435k
NIAID NIH HHS R21 AI119893NIAID NIH HHS R21 AI123594NIAID NIH HHS R21 AI150957
6 · The paper itself

Abstract

Entamoeba histolytica, an anaerobic protozoan, is an important global health problem. This parasite has a biphasic life cycle consisting of a dormant cyst stage which is environmentally resistant and transmits the infection, and the proliferative trophozoite stage which is motile and causes invasive disease. The stage conversion process remains poorly understood despite being central to amoebic biology. In this review, we will highlight recent progress in our understanding of Entamoeba stage conversion including dissecting transcriptome analysis in development, characterization of transcriptional networks, demonstration of epigenetic regulation, and role of small molecules that regulate Entamoeba development.

Indexed as

AnimalsEntamoeba histolyticaEntamoebiasisEpigenesis, GeneticGene Regulatory NetworksHumansLife Cycle StagesProtozoan ProteinsProtozoan Proteins

Identifiers

PMID33032142
PMCPMC7746589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.