ArticleNeuroImage. Clinical2020
Improved detection of focal cortical dysplasia using a novel 3D imaging sequence: Edge-Enhancing Gradient Echo (3D-EDGE) MRI.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Deep learning-based detection of focal cortical dysplasia in children: External validation of the MELD Graph and 3D-nnUNet pipelines.Neuroimage. Reports · 2026Article
- Ultra-high contrast MRI of the brain and spinal cord using directly acquired and synthetic BipoLAr Inversion Recovery (BLAIR) images.Quantitative imaging in medicine and surgery · 2026Review
- A comparative analysis of imaging-based algorithms for detecting focal cortical dysplasia type II in children.Scientific reports · 2025Article
- Article
- A closer look: pediatric neuroimaging at 7T.Pediatric radiology · 2025Review
- Epilepsy Diagnosis When the Routine Ancillary Tests Are Normal.Neurology international · 2025Review
- Integrating standard epilepsy protocol, ASL-perfusion, MP2RAGE/EDGE and the MELD-FCD classifier in the detection of subtle epileptogenic lesions: a 3 Tesla MRI pilot study.Neuroradiology · 2025Article
- Association of carotid atherosclerosis with brain tissue integrity and metabolic parameters in type 2 diabetes patients.Frontiers in endocrinology · 2025Article
- Advances in magnetic resonance imaging for the assessment of paediatric focal epilepsy: a narrative review.Translational pediatrics · 2024Review
- A radiomics nomogram based on multiparametric MRI for diagnosing focal cortical dysplasia and initially identifying laterality.BMC medical imaging · 2024Article
- Temporal pole blurring in temporal lobe epilepsy revealed by 3D Edge-Enhancing Gradient Echo MRI.The neuroradiology journal · 2024Article
- Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy.Neuroimage. Reports · 2023Article
- Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing.Clinical neuroradiology · 2023Article
- Pearls & Oy-sters: Harnessing New Diagnostic and Therapeutic Approaches to Treat a Patient With Genetic Drug-Resistant Focal Epilepsy.Neurology · 2023Article
- Edge-Enhancing Gradient-Echo MP2RAGE for Clinical Epilepsy Imaging at 7T.AJNR. American journal of neuroradiology · 2023Article
- Automatic segmentation of white matter hyperintensities and correlation analysis for cerebral small vessel disease.Frontiers in neurology · 2023Article
- The Role of the Three-Dimensional Edge-Enhancing Gradient Echo Sequence at 3T MRI in the Detection of Focal Cortical Dysplasia: A Technical Case Report and Literature Review.Neuropediatrics · 2022Review
- A Noise-robust and Overshoot-free Alternative to Unsharp Masking for Enhancing the Acuity of MR Images.Journal of digital imaging · 2022Article
- Imaging in medically refractory epilepsy at 3 Tesla: a 13-year tertiary adult epilepsy center experience.Insights into imaging · 2022Article
- MRI of focal cortical dysplasia.Neuroradiology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a common neurological disorder with focal cortical dysplasia (FCD) being one of the most common lesional causes. Detection of FCD by MRI is a major determinant of surgical outcome. Evolution of MRI sequences and hardware has greatly increased the detection rate of FCD, but these gains have largely been related to the more visible Type IIb FCD, with Type I and IIa remaining elusive. While most sequence improvements have relied on increasing contrast between gray and white matter, we propose a novel imaging approach, 3D Edge-Enhancing Gradient Echo (3D-EDGE), to directly image the gray-white boundary. By acquiring images at an inversion time where gray and white matter have equal signal but opposite phases, voxels with a mixture of gray and white matter (e.g., at the gray-white boundary) will have cancellation of longitudinal magnetization producing a thin area of signal void at the normal boundary. By creating greater sensitivity for minor changes in T1 relaxation, microarchitectural abnormalities present in FCD produce greater contrast than on other common MRI sequences. 3D-EDGE had a significantly greater contrast ratio between lesion and white matter for FCD compared to MP2RAGE (98% vs 17%; p = 0.0006) and FLAIR (98% vs 19%; p = 0.0006), which highlights its potential to improve outcomes in epilepsy. We present a discussion of the framework for 3D-EDGE, optimization strategies, and analysis of a series of FCDs to highlight the benefit of 3D-EDGE in FCD detection compared to commonly used sequences in epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.