Evidence map›Paper›PMID 33031765›Full record

ArticleCell host & microbe2020

Mining the Antibody Repertoire for Solutions to SARS-CoV-2.

Wenzhao Meng, Aaron M Rosenfeld, Eline T Luning Prak

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Moving beyond Titers.Vaccines · 2022
    Review
  2. Functional andFrontiers in veterinary science · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Wenzhao MengPerelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aaron M RosenfeldPerelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eline T Luning PrakPerelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: luning@pennmedicine.upenn.edu.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
University of Pennsylvania Clinical Autoimmunity Center of ExcellenceUM1AI144288 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BAR-OR, AMIT, PAYNE, AIMEE S · 2019 to 2023
$551k
NCI NIH HHS P30 CA016520NIAID NIH HHS P01 AI106697NIAID NIH HHS UM1 AI144288NIDDK NIH HHS UC4 DK112217
6 · The paper itself

Abstract

In this issue of Cell Host & Microbe, Nielsen and colleagues sequence antibody repertoires of patients with severe COVID-19 to reveal potentially convergent features on the background of a larger, polyclonal response. Their findings suggest that, as databases improve, it may be possible to monitor virus-specific B cells after infection or vaccination using antibody sequencing.

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralSevere Acute Respiratory SyndromeAntibodies, ViralAntibody FormationBetacoronavirusB-LymphocytesCOVID-19HumansImmunoglobulin GSARS-CoV-2Antibodies, ViralImmunoglobulin G

Identifiers

PMID33031765
PMCPMC7539899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.