ArticleCell2020
An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration.
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Lasting aversive consequences of a single dose of 4-hydroxytamoxifen.bioRxiv : the preprint server for biology · 2026Article
- The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.Acta pharmacologica Sinica · 2026Article
- Article
- Specialized outputs and behavioral contributions of Purkinje cell subtypes.bioRxiv : the preprint server for biology · 2026Article
- The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome.The Journal of comparative neurology · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Corticothalamic neurons in motor cortex have a permissive role in motor execution.Nature communications · 2025Article
- Dissociable roles of distinct thalamic circuits in learning reaches to spatial targets.Nature communications · 2025Article
- Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Cell-type-specific auditory responses in the striatum are shaped by feedforward inhibition.Cell reports · 2025Article
- Article
- Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses.bioRxiv : the preprint server for biology · 2024Article
- Exploration biases forelimb reaching strategies.Cell reports · 2024Article
- Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.Cell reports · 2024Article
- Line- and sex-dependent effects of juvenile stress on contextual fear- and anxiety-related behavior in high- and low-alcohol-preferring mouse lines.Behavioural brain research · 2024Article
- Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.Nature communications · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
Exploration of novel environments ensures survival and evolutionary fitness. It is expressed through exploratory bouts and arrests that change dynamically based on experience. Neural circuits mediating exploratory behavior should therefore integrate experience and use it to select the proper behavioral output. Using a spatial exploration assay, we uncovered an experience-dependent increase in momentary arrests in locations where animals arrested previously. Calcium imaging in freely exploring mice revealed a genetically and projection-defined neuronal ensemble in the basolateral amygdala that is active during self-paced behavioral arrests. This ensemble was recruited in an experience-dependent manner, and closed-loop optogenetic manipulation of these neurons revealed that they are sufficient and necessary to drive experience-dependent arrests during exploration. Projection-specific imaging and optogenetic experiments revealed that these arrests are effected by basolateral amygdala neurons projecting to the central amygdala, uncovering an amygdala circuit that mediates momentary arrests in familiar places but not avoidance or anxiety/fear-like behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.