ArticleAngewandte Chemie (International ed. in English)2021
Mechanochemical Solvent-Free Catalytic C-H Methylation.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- RuNature communications · 2026Article
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Mechanochemical ligand-controlled regiodivergent hydroarylation of alkenes via iron-catalyzed C-H activation.Nature communications · 2025Article
- Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds.Angewandte Chemie (International ed. in English) · 2025Review
- Solventless Catalytic C-H and C-X Functionalization without Ball Milling.The Journal of organic chemistry · 2025Article
- Advances in Mechanochemical Methods for One-Pot Multistep Organic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Meta-Dimethylation of Arenes via Catellani Reaction from Aryl Thianthrenium Salts.Angewandte Chemie (International ed. in English) · 2025Article
- Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity.The Journal of organic chemistry · 2024Article
- Solvent-free selective hydrogenation of nitroaromatics to azoxy compounds over Co single atoms decorated on NbNature communications · 2024Article
- Allylation ofAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2024Article
- Allylation of C-, N-, and O-Nucleophiles via a Mechanochemically-Driven Tsuji-Trost Reaction Suitable for Late-Stage Modification of Bioactive Molecules.Angewandte Chemie (International ed. in English) · 2024Article
- Late-Stage C-H Functionalization of Azines.Chemical reviews · 2023Review
- Transition-Metal-Catalyzed C-H Bond Activation for the Formation of C-C Bonds in Complex Molecules.Chemical reviews · 2023Review
- Ruthenium-Catalyzed Monoselective C-H Methylation andJACS Au · 2022Article
- From Inert to Catalytically Active Milling Media: Galvanostatic Coating for Direct Mechanocatalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Theoretical Study for Evaluating and Discovering Organic Hydride Compounds as Potential Novel Methylation Reagents.ACS omega · 2022Article
- The Direct Mechanocatalytic Suzuki-Miyaura Reaction of Small Organic Molecules.Angewandte Chemie (International ed. in English) · 2022Article
- Mechanochemical Dimerization of Aldoximes to Furoxans.Molecules (Basel, Switzerland) · 2022Article
- Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents.The Journal of organic chemistry · 2022Article
- Mechanochemical Organocatalysis: Do High Enantioselectivities Contradict What We Might Expect?ChemSusChem · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The mechanochemical, solvent-free, highly regioselective, rhodium-catalyzed C-H methylation of (hetero)arenes is reported. The reaction shows excellent functional-group compatibility and is demonstrated to work for the late-stage C-H methylation of biologically active compounds. The method requires no external heating and benefits from considerably shorter reaction times than previous solution-based C-H methylation protocols. Additionally, the mechanochemical approach is shown to enable the efficient synthesis of organometallic complexes that are difficult to generate conventionally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.