Evidence map›Paper›PMID 33031622›Full record

SynthesisThe oncologist2021

Impact of Primary Tumor Location on Survival After Curative Resection in Patients with Colon Cancer: A Meta-Analysis of Propensity Score-Matching Studies.

Mitsuru Ishizuka, Takayuki Shimizu, Norisuke Shibuya, Kazutoshi Takagi, Hiroyuki Hachiya, Yusuke Nishi, Kotaro Suda, Taku Aoki, Keiichi Kubota

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The oncologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mitsuru IshizukaDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.ORCID 0000-0003-3241-1480
Takayuki ShimizuDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Norisuke ShibuyaDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Kazutoshi TakagiDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Hiroyuki HachiyaDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Yusuke NishiDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Kotaro SudaDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Taku AokiDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.
Keiichi KubotaDepartment of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent retrospective subgroup analyses of patients with unresectable colon cancer (CC) receiving systemic chemotherapy have demonstrated that there is a significant difference in treatment outcome between patients with right-sided CC (RSCC) and those with left-sided CC (LSCC). However, it is impossible to divide patients with CC randomly into RSCC and LSCC groups before surgery. Therefore, the aim of this study is to explore the impact of primary tumor location (PTL) on survival after curative surgery for patients with CC using propensity score-matching (PSM) studies instead of randomization. MATERIALS AND

methodsWe performed a comprehensive electronic search of the literature up to January 2019 to identify studies that had used databases allowing comparison of postoperative survival between patients with RSCC and those with LSCC. To integrate the impact of PTL on 5-year overall survival (OS) after curative surgery, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI) for the selected PSM studies.

resultsFive studies involving a total of 398,687 patients with CC were included in this meta-analysis. Among 205,641 patients with RSCC, 69,091 (33.6%) died during the observation period, whereas among 193,046 patients with LSCC, 63,380 (32.8%) died during the same period. These results revealed that patients with RSCC and those with LSCC had almost the same 5-year OS (RR, 0.98; 95% CI, 0.89-1.07; p = .64; I

conclusionThis meta-analysis has demonstrated that there was no significant difference in 5-year OS between patients with RSCC and those with LSCC after curative resection. IMPLICATIONS FOR PRACTICE: To integrate the impact of primary tumor location (PTL) on 5-year overall survival (OS) after curative surgery, five propensity score-matching (PSM) studies involving a total of 398,687 patients with colon cancer (CC) were included in this meta-analysis. Among 205,641 patients with right-sided CC (RSCC), 69,091 (33.6%) died during the observation period, whereas among 193,046 patients with left-sided CC (LSCC), 63,380 (32.8%) died during the same period. These results revealed that patients with RSCC and those with LSCC had almost the same 5-year OS (risk ratio, 0.98; 95% confidence interval, 0.89-1.07; p = .64; I

Indexed as

Colonic NeoplasmsHumansPrognosisPropensity ScoreRetrospective StudiesTreatment OutcomeLeft-sided colon cancerMatching studyMeta-analysisPrimary tumor locationPropensity scoreRight-sided colon cancer

Identifiers

PMID33031622
PMCPMC7930413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.