Evidence map›Paper›PMID 33031156›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2020

Brief Report: Proportion and Predictors of Adult TB Contacts Accepting HIV Testing During an Active TB Case Finding Intervention in South Africa.

Nicholas W Albaugh, Bareng A S Nonyane, Lesego Mmolawa, Tsundzukani Siwelana, Limakatso Lebina, David W Dowdy, Neil Martinson, Colleen F Hanrahan

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas W AlbaughDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Bareng A S NonyaneDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Lesego MmolawaPerinatal HIV Research Unit, Soweto, South Africa; and.
Tsundzukani SiwelanaPerinatal HIV Research Unit, Soweto, South Africa; and.
Limakatso LebinaPerinatal HIV Research Unit, Soweto, South Africa; and.
David W DowdyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Neil MartinsonPerinatal HIV Research Unit, Soweto, South Africa; and.
Colleen F HanrahanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Funding

Innovative Contact Tracing Strategies for Detecting TB in Mobile Rural and Urban South African PopulationsR01AI147681 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DOWDY, DAVID WESLEY · 2019 to 2023
$3.2M
Comparative Effectiveness/Implementation of TB Case Finding in Rural South AfricaR01AI116787 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DOWDY, DAVID WESLEY · 2015 to 2019
$3.1M
NIAID NIH HHS R01 AI116787NIAID NIH HHS R01 AI147681
6 · The paper itself

Abstract

backgroundMany individuals at risk for HIV may be reached through active TB case finding interventions in areas with highly prevalent co-epidemics of TB/HIV.

methodsWe analyzed data from a cluster-randomized trial of 2 TB case finding strategies: facility-based screening and contact investigation of newly identified TB cases. In both arms, on-site rapid HIV testing was offered to all contacts older than 18 months who did not self-report HIV-positive status. Those who were HIV infected were referred appropriately. All contacts 15 years and older were included in this analysis.

resultsAmong 2179 contacts identified, 50% (1092) accepted HIV testing and counselling, of whom 6.3% (68) tested HIV-positive. Contacts who were unemployed [adjusted prevalence ratio (aPR) 1.14, 95% confidence interval (CI): 1.04 to 1.25], had not been to a clinic (aPR 1.09, 95% CI: 1.02 to 1.18) or HIV tested (aPR 1.25, 95% CI: 1.14 to 1.39) 6 months before, and those reporting gastrointestinal symptoms (aPR 1.22, 95% CI: 0.98 to 1.52) and genitourinary symptoms (aPR 1.30, 95% CI: 1.17 to 1.45) were significantly associated with accepting HIV testing. Women [adjusted odds ratio (aOR) 2.19, 95% CI: 1.26 to 3.81], individuals with a past history of tuberculosis (aOR 1.96, 95% CI: 0.93 to 4.14), and those not HIV tested 6 months before (aOR 2.20, 95% CI: 1.28 to 3.79) were significantly associated with testing HIV-positive.

conclusionOffering HIV testing in the context of active tuberculosis case finding represents an opportunity to identify a large proportion of previously undiagnosed individuals with HIV in a population that might otherwise not seek testing.

Indexed as

AdolescentAdultCoinfectionFemaleHIV InfectionsHumansMalePatient Acceptance of Health CareSouth AfricaTuberculosis, PulmonaryYoung Adult

Identifiers

PMID33031156
PMCPMC8219244

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.