Evidence map›Paper›PMID 33030608›Full record

ArticleJournal of neurology2020

Bilateral vestibulopathy: beyond imbalance and oscillopsia.

F M P Lucieer, R Van Hecke, L van Stiphout, S Duijn, A Perez-Fornos, N Guinand, V Van Rompaey, H Kingma, M Joore, R van de Berg

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07709143 (The Clinical Trial Protocol), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07709143 recruitingnot on this mapstarted 2024, after this paper: background citation

The Clinical Trial Protocol: MRI Performance and Risk Factors of Bilateral Vestibular Hypofunction: A Multi-center Cross-sectional Study

TypeobservationalSponsorShanghai 6th People's HospitalRan2024 to 2029Enrolled120ConditionsBilateral Vestibular Hypofunction, Bilateral Vestibulopathy, PresbyvestibulopathyArmsMultimodal Neuroimaging and Vestibular Function Assessment
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Investigation of Vestibular Dysfunction Requires Renewed Research Enthusiasm.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Pooled it
  2. Driving ability in patients with dizziness: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  3. Pooled it
  4. Rapid acclimatization to baseline stimulation with a multi-canal vestibulocochlear implant.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Trial
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  7. Vestibular Function Drives Gaze Stability in Locomoting Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  9. Bilateral vestibulopathy - insight in impact on quality of life and economic burden.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  13. The impact of bilateral vestibulopathy on quality of life: data from the Antwerp University Hospital registry.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

F M P LucieerDepartment of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands. f.lucieer@gmail.com.ORCID http://orcid.org/0000-0001-9150-6952
R Van HeckeDepartment of Rehabilitation Sciences, University of Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0002-6428-890X
L van StiphoutDepartment of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-4981-0584
S DuijnFaculty of Health, Medicine and life Sciences, University of Maastricht, Maastricht, The Netherlands.
A Perez-FornosService of Otorhinolaryngology Head and Neck Surgery, Department of Clinical Neurosciences,, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-3911-8826
N GuinandService of Otorhinolaryngology Head and Neck Surgery, Department of Clinical Neurosciences,, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-6004-8768
V Van RompaeyFaculty of Physics, Tomsk State Research University, Tomsk, Russian Federation.ORCID http://orcid.org/0000-0003-0912-7780
H KingmaDepartment of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-9880-8224
M JooreDepartment of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Care and Public Health Research Institute (CAPHRI) of the Faculty of Health, Medicine and Life Sciences of Maastricht University (FHML), Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-5649-6768
R van de BergDepartment of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-9734-8668
Maastricht University · NLMaastricht University Medical Centre · NLUniversity Hospital of Geneva · CHUniversity of Antwerp · BENational Research Tomsk State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo optimize the current diagnostic and treatment procedures for patients with bilateral vestibulopathy (BV), this study aimed to determine the complete spectrum of symptoms associated with BV.

methodA prospective mixed-method study design was used. Qualitative data were collected by performing semi-structured interviews about symptoms, context, and behavior. The interviews were recorded and transcribed until no new information was obtained. Transcriptions were analyzed in consensus by two independent researchers. In comparison to the qualitative results, quantitative data were collected using the Dizziness Handicap Inventory (DHI), Hospital Anxiety and Depression Scale (HADS) and a health-related quality of life questionnaire (EQ-5D-5L).

resultsEighteen interviews were transcribed. Reported symptoms were divided into fourteen physical symptoms, four cognitive symptoms, and six emotions. Symptoms increased in many situations, such as darkness (100%), uneven ground (61%), cycling (94%) or driving a car (56%). These symptoms associated with BV often resulted in behavioral changes: activities were performed more slowly, with greater attention, or were avoided. The DHI showed a mean score of severe handicap (54.67). The HADS questionnaire showed on average normal results (anxiety = 7.67, depression = 6.22). The EQ-5D-5L demonstrated a mean index value of 0.680, which is lower compared to the Dutch age-adjusted reference 0.839 (60-70 years).

conclusionBV frequently leads to physical, cognitive, and emotional complaints, which often results in a diminished quality of life. Importantly, this wide range of symptoms is currently underrated in literature and should be taken into consideration during the development of candidacy criteria and/or outcome measures for therapeutic interventions such as the vestibular implant.

Indexed as

Bilateral VestibulopathyAdolescentAdultAgedChildChild, PreschoolDizzinessHumansInfantMiddle AgedProspective StudiesQuality of LifeVertigoYoung AdultBilateral vestibular hypofunctionBilateral vestibulopathyOutcome measuresSymptomsVestibular implantVestibular prosthesis

Identifiers

PMID33030608
PMCPMC7718190
OpenAlexW3091923132

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.