Evidence map›Paper›PMID 33030596›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol.

Jordan M Cloyd, Sarah Hyman, Tanya Huwig, Christina Monsour, Heena Santry, Celia Wills, Allan Tsung, John F P Bridges

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordan M CloydDepartment of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA. jordan.cloyd@osumc.edu.ORCID http://orcid.org/0000-0002-2373-8433
Sarah HymanCollege of Public Health, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Tanya HuwigDepartment of Biomedical Informatics, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Christina MonsourDepartment of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Heena SantryDepartment of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Celia WillsCollege of Nursing, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Allan TsungDepartment of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
John F P BridgesDepartment of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
NCATS NIH HHS UL1TR002733 from the National Center For Advancing Translational Sciences
6 · The paper itself

Abstract

purposeNeoadjuvant therapy (NT) is increasingly being offered to patients with pancreatic ductal adenocarcinoma (PDAC) prior to surgical resection. However, the experience and quality of life (QOL) of patients undergoing NT are poorly understood.

methodsA systematic review of the Cinahl, Embase, Medline, Pubmed, Scopus, and Web of Science databases was conducted to evaluate the available literature pertaining to the experience and QOL of patient's undergoing NT for PDAC.

resultsAmong 6041 articles screened, only six met criteria for full-text review including three prospective clinical trials of NT with QOL secondary endpoints. Overall, global QOL during or following NT did not significantly change from baseline. Pain scores seemed to improve during NT while the impact of NT on physical functioning varied across studies. No studies were identified evaluating other aspects of the patient experience.

conclusionAlthough NT appears to have a minor impact on the QOL of patients with PDAC, this systematic review identified significant evidence gaps in the literature. A protocol of a prospective observational cohort study utilizing a digital smartphone app that aims to evaluate the patient experience and longitudinal QOL of patients with PDAC undergoing NT is presented.

Indexed as

AdenocarcinomaCarcinoma, Pancreatic DuctalNeoadjuvant TherapyQuality of LifeCohort StudiesFemaleHumansLongitudinal StudiesMaleObservational Studies as TopicProspective StudiesPalliative carePancreatic ductal adenocarcinomaPatient preferencesPatient-reported outcomesPsychological impactSupportive care

Identifiers

PMID33030596

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.