Evidence map›Paper›PMID 33030439›Full record

ArticleJMIR research protocols2020

The Analgesic Effect of Electroencephalographic Neurofeedback for People With Chronic Pain: Protocol for a Systematic Review and Meta-analysis.

Negin Hesam-Shariati, Wei-Ju Chang, James H McAuley, Andrew Booth, Zina Trost, Chin-Teng Lin, Toby Newton-John, Sylvia M Gustin

Open access · goldAbstract read
In one paragraph

Article in JMIR research protocols, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Negin Hesam-ShariatiCentre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.ORCID https://orcid.org/0000-0003-0829-7016
Wei-Ju ChangCentre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.ORCID https://orcid.org/0000-0003-0524-4883
James H McAuleyCentre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.ORCID https://orcid.org/0000-0002-0550-828X
Andrew BoothSchool of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.ORCID https://orcid.org/0000-0003-4808-3880
Zina TrostDepartment of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, United States.ORCID https://orcid.org/0000-0002-3345-0337
Chin-Teng LinAustralian Artificial Intelligence Institute, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0001-8371-8197
Toby Newton-JohnGraduate School of Health, University of Technology Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0003-4219-4985
Sylvia M GustinCentre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.ORCID https://orcid.org/0000-0002-9613-9845
UNSW Sydney · AUUniversity of Technology Sydney · AUNeuroscience Research Australia · AUUniversity of Sheffield · GBVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic pain is a global health problem, affecting around 1 in 5 individuals in the general population. The understanding of the key role of functional brain alterations in the generation of chronic pain has led researchers to focus on pain treatments that target brain activity. Electroencephalographic neurofeedback attempts to modulate the power of maladaptive electroencephalography frequency powers to decrease chronic pain. Although several studies have provided promising evidence, the effect of electroencephalographic neurofeedback on chronic pain is uncertain.

objectiveThis systematic review aims to synthesize the evidence from randomized controlled trials to evaluate the analgesic effect of electroencephalographic neurofeedback. In addition, we will synthesize the findings of nonrandomized studies in a narrative review.

methodsWe will apply the search strategy in 5 electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycInfo, and CINAHL) for published studies and in clinical trial registries for completed unpublished studies. We will include studies that used electroencephalographic neurofeedback as an intervention for people with chronic pain. Risk-of-bias tools will be used to assess methodological quality of the included studies. We will include randomized controlled trials if they have compared electroencephalographic neurofeedback with any other intervention or placebo control. The data from randomized controlled trials will be aggregated to perform a meta-analysis for quantitative synthesis. The primary outcome measure is pain intensity assessed by self-report scales. Secondary outcome measures include depressive symptoms, anxiety symptoms, and sleep quality measured by self-reported questionnaires. We will investigate the studies for additional outcomes addressing adverse effects and resting-state electroencephalography analysis. Additionally, all types of nonrandomized studies will be included for a narrative synthesis. The intended and unintended effects of nonrandomized studies will be extracted and summarized in a descriptive table.

resultsEthics approval is not required for a systematic review, as there will be no patient involvement. The search for this systematic review commenced in July 2020, and we expect to publish the findings in early 2021.

conclusionsThis systematic review will provide recommendations for researchers and health professionals, as well as people with chronic pain, about the evidence for the analgesic effect of electroencephalographic neurofeedback.

trial registrationInternational Prospective Register of Systematic Reviews (PROSPERO) CRD42020177608; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=177608. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/22821.

Indexed as

chronic painEEG neurofeedbackmeta-analysissystematic review

Identifiers

PMID33030439
PMCPMC7582146
OpenAlexW3091781640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.