ArticleAutophagy2021
Metformin rescues muscle function in BAG3 myofibrillar myopathy models.
Open access · bronzeAbstract read
In one paragraph
Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- BAG3 gene therapy emerges as a potential treatment for myofibrillar myopathies.Molecular therapy. Advances · 2026Article
- Review
- Autophagy activation via BAG3 gene therapy improves phenotype in a mouse model of LGMD1A.Molecular therapy. Advances · 2026Article
- Disease spectrum and long-term prognosis of patients with BAG3-associated neuromuscular diseases in Europe.Brain : a journal of neurology · 2025Article
- Integrative Approaches to Myopathies and Muscular Dystrophies: Molecular Mechanisms, Diagnostics, and Future Therapies.International journal of molecular sciences · 2025Review
- Article
- Dominantly inherited muscle disorders: understanding their complexity and exploring therapeutic approaches.Disease models & mechanisms · 2024Review
- Congenital myopathies: pathophysiological mechanisms and promising therapies.Journal of translational medicine · 2024Review
- Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model.Human molecular genetics · 2024Article
- CRIMP: a CRISPR/Cas9 insertional mutagenesis protocol and toolkit.Nature communications · 2024Article
- Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP.JCI insight · 2024Article
- Standardization of zebrafish drug testing parameters for muscle diseases.Disease models & mechanisms · 2024Article
- Desmin mutations impact the autophagy flux in C2C12 cell in mutation-specific manner.Cell and tissue research · 2023Article
- Article
- Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy.Disease models & mechanisms · 2023Article
- Two Cases of Myofibrillar Myopathies: Genetic and Quality of Life Study.Muscles (Basel, Switzerland) · 2023Article
- Elucidation of bioinformatic-guided high-prospect drug repositioning candidates for DMD via Swanson linking of target-focused latent knowledge from text-mined categorical metadata.Frontiers in cell and developmental biology · 2023Article
- Rare clinical phenotype of filaminopathy presenting as restrictive cardiomyopathy and myopathy in childhood.Orphanet journal of rare diseases · 2022Article
- Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy.Human molecular genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 4 countries.
Avnika A RupareliaSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-1012-0079
Emily A McKaigeSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-3313-7535
Caitlin WilliamsSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-5120-1852
Keith E SchulzeMonash Micro Imaging, Monash University, Melbourne, Australia.ORCID 0000-0001-7261-3314
Margit FuchsCentre de Recherche Sur le Cancer de l'Université Laval, Ville de Québec, Canada.
Viola OorschotMonash Ramaciotti Centre for Structural Cryo-Electron Microscopy, Monash University, Melbourne, Australia.ORCID 0000-0002-8122-8271
Emmanuelle LaceneInstitut de Myologie, Laboratoire de Pathologie Risler, APHP, Centre de Référence de Pathologie Neuromusculaire Nord/Est/Ile-de-France, Paris, France.
Mirella MeregalliStem Cell Laboratory, Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Centro Dino Ferrari, Milan, Italy.
Clara LeeSchool of Biological Sciences, Monash University, Melbourne, Australia.
Rita J SerranoSchool of Biological Sciences, Monash University, Melbourne, Australia.
Emily C BaxterSchool of Biological Sciences, Monash University, Melbourne, Australia.
Keyne MonroSchool of Biological Sciences, Monash University, Melbourne, Australia.
Yvan TorrenteStem Cell Laboratory, Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Centro Dino Ferrari, Milan, Italy.
Georg RammMonash Ramaciotti Centre for Structural Cryo-Electron Microscopy, Monash University, Melbourne, Australia.ORCID 0000-0003-3596-2288
Tanya StojkovicInstitut de Myologie, Centre de Référence des Maladies Neuromusculaires, Hôpital Pitié-Salpétrière, Assistance-Publique Hôpitaux de Paris, Sorbonne Université, Paris, France.
Josée N LavoieCentre de Recherche Sur le Cancer de l'Université Laval, Ville de Québec, Canada.ORCID 0000-0001-6912-1132
Robert J Bryson-RichardsonSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-9501-8208
Monash University · AUFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversité Laval · CAAssistance Publique – Hôpitaux de Paris · FRAustralian Regenerative Medicine Institute · AUSorbonne Université · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dominant
Indexed as
Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsMetforminMyopathies, Structural, CongenitalAnimalsAutophagyHSP40 Heat-Shock ProteinsHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMolecular ChaperonesMuscle ProteinsMusclesMutationNerve Tissue ProteinsZebrafishAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBAG3 protein, humanBAG3 protein, zebrafishDNAJB6 protein, humanFHL1 protein, humanHSP40 Heat-Shock ProteinsIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMetforminMolecular ChaperonesMuscle ProteinsNerve Tissue ProteinsZebrafish ProteinsAutophagyBAG3metforminmusclemyofibrillar myopathyzebrafish
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.