ArticlePathogens and disease2020
Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples.
Article in Pathogens and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Antigen rapid tests, nasopharyngeal PCR and saliva PCR to detect SARS-CoV-2: A prospective comparative clinical trial.PloS one · 2023Trial
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- Neglected tropical diseases: recent trends and challenges associated with its rapid diagnosis and effective therapeutic strategies.Frontiers in pharmacology · 2026Review
- Temporal changes in fecal microbiota of patients infected with COVID-19: a longitudinal cohort.BMC infectious diseases · 2023Observational
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- Molecular Detection of Neglected Tropical Diseases: The Case for Automated Near-Point-of-Care Diagnosis of Leishmaniasis.The American journal of tropical medicine and hygiene · 2023Article
- Quantitative analysis of different respiratory specimens on two automated test systems for detection of SARS-CoV-2 RNA.Diagnostic microbiology and infectious disease · 2023Article
- Comparison of Nasopharyngeal and Saliva Swab Nucleic Acid Amplification and Rapid Antigen Testing To Detect Omicron SARS-CoV-2 Variant of Concern: a Prospective Clinical Trial (OMICRON).Microbiology spectrum · 2022Article
- Observational
- Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study.Journal of general internal medicine · 2022Article
- Multicenter Technical Validation of 30 Rapid Antigen Tests for the Detection of SARS-CoV-2 (VALIDATE).Microorganisms · 2021Article
- Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.Viruses · 2021Article
- Increasing diagnostic possibilities using the geneLEAD VIII platform for detection of SARS-CoV-2.Journal of virological methods · 2021Article
- A new qualitative RT-PCR assay detecting SARS-CoV-2.Scientific reports · 2021Article
- Size and duration of COVID-19 clusters go along with a high SARS-CoV-2 viral load: A spatio-temporal investigation in Vaud state, Switzerland.The Science of the total environment · 2021Article
- Article
- Evaluation of sixteen ELISA SARS-CoV-2 serological tests.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
- SARS-CoV-2 seroprevalence in healthcare workers of a Swiss tertiary care centre at the end of the first wave: a cross-sectional study.BMJ open · 2021Article
- The dark side of SARS-CoV-2 rapid antigen testing: screening asymptomatic patients.New microbes and new infections · 2021Article
- Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesIn order to cope with the rapid spread of the COVID-19 pandemic, we introduced on our in-house high-throughput molecular diagnostic platform (MDx Platform) a real-time reverse transcriptase PCR (RT-PCR) to detect the SARS-CoV-2 from any clinical specimens. The aim of this study was to compare the RT-PCR results obtain with the MDx Platform and the commercial assay cobas SARS-CoV-2 (Roche) on nasopharyngeal swab and other clinical specimens including sputum, bronchial aspirate, bronchoalveolar lavage and anal swabs.
methodsSamples received in our laboratory from patients suspected of COVID-19 (n = 262) were tested in parallel with our MDx platform SARS-CoV-2 PCR and with the cobas SARS-CoV-2 test.
resultsThe overall agreement between the two tests for all samples tested was 99.24% (260/262), which corresponded to agreements of 100% (178/178) on nasopharyngeal swabs, 95.45% (42/44) on lower respiratory tract specimen with discordant resultS obtained for very high cycle threshold (Ct) value and 100% (40/40) on anorectal swabs. The Ct values for nasopharyngeal swabs displayed an excellent correlation (R2 > 96%) between both tests.
conclusionsThe high agreements between the cobas SARS-CoV-2 test and the MDx platform supports the use of both methods for the diagnostic of COVID-19 on various clinical samples. Very few discrepant results may occur at very low viral load.
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