ArticleJournal of geriatric psychiatry and neurology2022
Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia.
Article in Journal of geriatric psychiatry and neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Apathy Associated with Alzheimer's Disease.Current Alzheimer research · 2024Pooled it
- Depression and apathy in frontotemporal dementia: a short assessment of facts and outlook.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Neuropsychiatric Symptoms in Patients With Pathologically Confirmed Comorbid Alzheimer Disease and Frontotemporal Lobar Degeneration.Neurology · 2026Article
- Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- Advances in the study of apathy related to cerebral small vessel disease.Frontiers in neurology · 2025Review
- Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Neuropsychiatric symptoms and imbalance of atrophy in behavioral variant frontotemporal dementia.Human brain mapping · 2023Article
- Cortical signature of depressive symptoms in frontotemporal dementia: A surface-based analysis.Annals of clinical and translational neurology · 2023Article
- Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in neurocognitive disorders.International journal of geriatric psychiatry · 2023Review
- The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.Emerging topics in life sciences · 2022Article
- Towards Defining the Neuroanatomical Basis of Late-Onset Psychiatric Symptoms.Journal of geriatric psychiatry and neurology · 2022Review
- A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia.Brain : a journal of neurology · 2022Review
- Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo understand the differential neuroanatomical substrates underlying apathy and depression in Frontotemporal dementia (FTD).
methodsT1-MRIs and clinical data of patients with behavioral and aphasic variants of FTD were obtained from an open database. Cortical thickness was derived, its association with apathy severity and difference between the depressed and not depressed were examined with appropriate covariates.
resultsApathy severity was significantly associated with cortical thinning of the lateral parts of the right sided frontal, temporal and parietal lobes. The right sided orbitofrontal, parsorbitalis and rostral anterior cingulate cortex were thicker in depressed compared to patients not depressed.
conclusionsGreater thickness of right sided ventromedial and inferior frontal cortex in depression compared to patients without depression suggests a possible requisite of gray matter in this particular area for the manifestation of depression in FTD. This study demonstrates a method for deriving neuroanatomical patterns across non-harmonized neuroimaging data in a neurodegenerative disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.