Evidence map›Paper›PMID 33030089›Full record

Trial reportJournal of dental research2021

G D Slade, R B Fillingim, R Ohrbach, H Hadgraft, J Willis, S J Arbes, I E Tchivileva

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  4. Do Diabetes and Genetic Polymorphisms in theJournal of clinical medicine · 2025
    Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

G D SladeCenter for Pain Research and Innovation, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
R B FillingimDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
R OhrbachDepartment of Oral and Maxillofacial Surgery, University at Buffalo, State University of New York, Buffalo, NY, USA.
H HadgraftRho Inc., Durham, NC, USA.
J WillisRho Inc., Durham, NC, USA.
S J ArbesRho Inc., Durham, NC, USA.ORCID 0000-0001-7767-0959
I E TchivilevaCenter for Pain Research and Innovation, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0968-0594
University of North Carolina at Chapel Hill · USUniversity at Buffalo, State University of New York · USUniversity of Florida · US

Funding

Effect of COMT genetic polymorphisms on response to propranolol therapy in TMDU01DE024169 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARBES, SAMUEL, FILLINGIM, ROGER B · 2014 to 2018
$4.7M
Effect of COMT genetic polymorphism on response to propranolol therapy in TMDR34DE022088 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARBES, SAMUEL, SLADE, GARY DOUGLAS · 2012 to 2012
$239k
NIDCR NIH HHS R34 DE022088NIDCR NIH HHS U01 DE024169
6 · The paper itself

Abstract

Propranolol is a nonselective β-adrenergic receptor antagonist that is efficacious in reducing facial pain. There is evidence that its analgesic efficacy might be modified by variants of the catechol-O-methyltransferase (

Indexed as

Catechol O-MethyltransferaseTemporomandibular Joint DisordersFacial PainGenotypeHumansPolymorphism, Single NucleotidePropranololCatechol O-MethyltransferaseCOMT protein, humanPropranololadrenergic beta-antagonistschronic painfacial paingenetic polymorphismpharmacogeneticsplacebos

Identifiers

PMID33030089
PMCPMC8163522
OpenAlexW3091873761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.