ArticleJournal of clinical neurology (Seoul, Korea)2020
Efficacy of a Second Brain Biopsy for Intracranial Lesions after Initial Negativity.
Article in Journal of clinical neurology (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A double threat: CNS toxoplasmosis and CMV encephalitis in a heart transplant recipientRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2026Article
- Non-diagnostic stereotactic intracranial biopsies: a 15-year institutional experience.Journal of neuro-oncology · 2026Article
- Fluorescence-aided stereotactic needle biopsies for brain tumors: experience on 516 cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Glioblastoma with markedly reduced contrast enhancement after corticosteroid administration: Increased density and reduced diffusion capability are noteworthy.Radiology case reports · 2025Article
- Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real-world cohort study.Annals of clinical and translational neurology · 2025Article
- Anticipating complications in stereotactic brain biopsy: a predictive approach.Neurosurgical review · 2025Article
- Insulin-like growth factor II mRNA binding protein 3 is highly expressed in primary diffuse large B-cell lymphoma of the CNS.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Advances, technological innovations, and future prospects in stereotactic brain biopsies.Neurosurgical review · 2022Review
- Roles and outcomes of stereotactic biopsy for adult patients with brainstem lesion.Journal of neuro-oncology · 2022Article
- Accuracy and safety of 101 consecutives neurosurgical procedures for newly diagnosed central nervous system lymphomas: a single-institution experience.Journal of neuro-oncology · 2022Observational
- Comparison meta-analysis of intraoperative MRI-guided needle biopsy versus conventional stereotactic needle biopsies.Neuro-oncology advancesReview
- Three-dimensional structured-light robot-assisted frameless versus frame-based stereotactic brain biopsy: a retrospective study of 54 patients.Frontiers in neurologyArticle
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Authors and funding
8 authors.
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Abstract
background and purposeThe rationale for performing a second brain biopsy after initial negativity is not well evaluated in the literature. This study was designed to 1) assess the efficacy of a second brain biopsy when the first biopsy was nondiagnostic, 2) identify possible factors associated with an increased diagnostic rate in the second biopsy, and 3) analyze additional morbidity induced by the second biopsy.
methodsWe performed a retrospective cohort study from 2009 to 2019, during which 1,919 patients underwent a brain biopsy, including 30 who were biopsied twice (1.6%). The specific histological diagnosis rate, diagnosis-associated factors, and complication rate were assessed for the 30 twice-biopsied patients.
resultsThe second biopsy allowed a specific histological diagnosis in 86.7% of the patients who had initially undergone a nondiagnostic brain biopsy [odds ratio (OR)=7.5, 95% confidence interval (CI)=3.0-18.7,
conclusionsPerforming a second brain biopsy in patients who have an initial nondiagnostic biopsy is effective in most cases. We advocate that a second biopsy be systematically considered in the diagnosis algorithm of these patients after it has been verified that molecular testing cannot help to obtain a diagnosis. Corticosteroid administration can lead to nondiagnostic biopsies and should be avoided when possible during the prebiopsy period.
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