Evidence map›Paper›PMID 33029957›Full record

ReviewJournal of clinical neurology (Seoul, Korea)2020

Clinical Approach to Autoimmune Epilepsy.

Yoonhyuk Jang, Dong Wook Kim, Kwang Ik Yang, Jung Ick Byun, Jong Geun Seo, Young Joo No, Kyung Wook Kang, Daeyoung Kim, Keun Tae Kim, Yong Won Cho and 2 more

Abstract readReview
In one paragraph

Review in Journal of clinical neurology (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Symptomatic treatments ofEncephalitis (Seoul, Korea) · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yoonhyuk JangDepartment of Neurology, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-3346-3357
Dong Wook KimDepartment of Neurology, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4484-0602
Kwang Ik YangDepartment of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0001-6343-6520
Jung Ick ByunDepartment of Neurology, Kyunghee University Hospital at Gangdong, Seoul, Korea.ORCID https://orcid.org/0000-0002-6224-4575
Jong Geun SeoDepartment of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0002-3944-5731
Young Joo NoDepartment of Neurology, Samsung Noble County, Yongin, Korea.ORCID https://orcid.org/0000-0002-0145-5707
Kyung Wook KangDepartment of Neurology, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.ORCID https://orcid.org/0000-0001-9362-8670
Daeyoung KimDepartment of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.ORCID https://orcid.org/0000-0001-9056-0017
Keun Tae KimDepartment of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea.ORCID https://orcid.org/0000-0002-7124-0736
Yong Won ChoDepartment of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea. neurocho@gmail.com.ORCID https://orcid.org/0000-0002-6127-1045
Soon Tae LeeDepartment of Neurology, Seoul National University Hospital, Seoul, Korea. staelee@snu.ac.kr.ORCID https://orcid.org/0000-0003-4767-7564
Drug Committee of Korean Epilepsy Society

Funding

GC Pharma
6 · The paper itself

Abstract

Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of "autoimmune" as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with immunotherapies. Autoimmune epilepsy presents with specific clinical manifestations, and various diagnostic approaches including cerebrospinal fluid analysis, neuroimaging, and autoantibody tests are essential for its differential diagnosis. The diagnosis is often indeterminate despite performing a thorough evaluation, and therefore empirical immunotherapy may be applied according to the judgment of the clinician. Autoimmune epilepsy often manifests as new-onset refractory status epilepticus (NORSE). A patient classified as NORSE should receive empirical immunotherapy as soon as possible. On the other hand, a morecautious, stepwise approach is recommended for autoimmune epilepsy that presents with episodic events. The type of autoimmune epilepsy is also an important factor to consider when choosing from among various immunotherapy options. Clinicians should additionally take the characteristics of antiepileptic drugs into account when using them as an adjuvant therapy. This expert opinion discusses the diagnostic and treatment approaches for autoimmune epilepsy from a practical point of view.

Indexed as

autoimmune encephalitisautoimmune epilepsyautoimmune epilepsy immunotherapyautoimmune epilepsy treatmentNORSErefractory status epilepticus

Identifiers

PMID33029957
PMCPMC7541993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.