Evidence map›Paper›PMID 33029895›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2020

Induced pluripotent stem cell reprogramming-associated methylation at the GABRA2 promoter and chr4p12 GABA

Alexandra Goetjen, Maegan Watson, Richard Lieberman, Kaitlin Clinton, Henry R Kranzler, Jonathan Covault

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandra GoetjenAlcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0001-5849-3336
Maegan WatsonAlcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Richard LiebermanAlcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Kaitlin ClintonAlcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Henry R KranzlerCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jonathan CovaultAlcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0002-3616-0431
University of Connecticut · USMental Illness Research, Education and Clinical Centers · US

Funding

Vulnerabilities for coping-related drinking among post-college young adultsP60AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 2008 to 2017
$17.5M
WHO COLLABORATIVE PROJECT ON MANAGEMENT OF HARMFUL ALCOHOL CONSUMPTIONP50AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 1985 to 2007
$13.6M
Pilot StudiesP50AA027055 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI COVAULT, JONATHAN M · 2019 to 2023
$7.8M
GABRA2 genetic variants and chromosome conformation in induced pluripotent stem cell-derived neural cellsF30AA027153 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GOETJEN, ALEXANDRA MARIE · 2018 to 2022
$230k
NIAAA NIH HHS F30 AA027153NIAAA NIH HHS P50 AA003510NIAAA NIH HHS P50 AA027055NIAAA NIH HHS P60 AA003510NIAAA NIH HHS P60 AA03510
6 · The paper itself

Abstract

Twin studies indicate that there is a significant genetic contribution to the risk of developing alcohol use disorder (AUD). With the exception of coding variants in ADH1B and ALDH2, little is known about the molecular effects of AUD-associated loci. We previously reported that the AUD-associated synonymous polymorphism rs279858 within the GABA

Indexed as

DNA MethylationPromoter Regions, GeneticAdultAlcoholismCellular ReprogrammingChromosomes, Human, Pair 4FemaleFibroblastsgamma-Aminobutyric AcidGenetic Predisposition to DiseaseHumansInduced Pluripotent Stem CellsMalePolymorphism, Single NucleotidePrognosisReceptors, GABA-AGABRA2 protein, humangamma-Aminobutyric AcidReceptors, GABA-Aalcohol use disorderepigeneticsGABAA receptor subunit genespromoter methylationstem cell-derived neural cultures

Identifiers

PMID33029895
PMCPMC8022112
OpenAlexW3091794330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.