Evidence map›Paper›PMID 33029765›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2021

The vaginal microbiota in the course of bacterial vaginosis treatment.

Romy D Zwittink, Ellen H A van den Munckhof, Maurine A Leverstein-van Hall, Kim Boers, Anco Molijn, Cornelis W Knetsch, Ed J Kuijper

Open access · hybridAbstract read
In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Vaginal microbiota stability over 18 months in young student women in France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Trial
  2. Review
  3. Article
  4. Article
  5. Molecular Exploration ofPathogens (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Updates on Group BMicroorganisms · 2022
    Review
  8. Vaginal Microbiome in Reproductive Medicine.Diagnostics (Basel, Switzerland) · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Romy D Zwittink *Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, The Netherlands. r.d.zwittink@lumc.nl.ORCID http://orcid.org/0000-0002-0537-6838
Ellen H A van den Munckhof *Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.
Maurine A Leverstein-van HallDDL Diagnostic Laboratory, Rijswijk, The Netherlands.
Kim BoersDepartment of Gynaecology, Haaglanden Medical Centre, The Hague, The Netherlands.
Anco MolijnDDL Diagnostic Laboratory, Rijswijk, The Netherlands.
Cornelis W KnetschDDL Diagnostic Laboratory, Rijswijk, The Netherlands.
Ed J KuijperCenter for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLDDL Diagnostic Laboratory · NLAlrijne Ziekenhuis · NLMedisch Centrum Haaglanden · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial vaginosis (BV) is perceived as a condition of disrupted vaginal microbiota, but remains of unknown aetiology. In this study, vaginal microbiota composition was determined in twenty-one women with BV, before and after treatment with metronidazole or clindamycin. Microbiota composition varied greatly between women and defining a (un)healthy vaginal microbiota state remains elusive, challenging BV diagnosis and treatment. While relative abundance of Lactobacillus increased after antibiotic treatment in two-third of women, its abundance was not associated with treatment outcome. Instead, remaining complaints of abnormal vaginal discharge were more common after metronidazole treatment and associated with increased relative abundance of Ureaplasma.

Indexed as

AdultAnti-Bacterial AgentsBacteriaClindamycinFemaleHost SpecificityHumansMetronidazoleMicrobiotaRNA, Ribosomal, 16SVaginaVaginal DischargeVaginosis, BacterialAnti-Bacterial AgentsClindamycinMetronidazoleRNA, Ribosomal, 16S16S rRNA gene amplicon sequencingAntibioticsBacterial vaginosisClindamycinMetronidazoleMicrobiota

Identifiers

PMID33029765
PMCPMC7892685
OpenAlexW3092399210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.