Evidence map›Paper›PMID 33029729›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

A rare case of atypical spinal neurocytoma with EGFR mutation in a 12-year-old boy.

Beibei Yu, Jiatong Li, Linkai Jing, Weitao Man, Guihuai Wang

Abstract readCase Reports
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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Extraventricular neurocytomas: a systematic review of the literature in the pediatric population.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Beibei YuDepartment of Neurosurgery, Changgung Hospital, Clinical Institute for Neuroscience, Medical Center, Tsinghua University, Beijing, 102218, China.ORCID 0000-0002-9076-5597
Jiatong LiSchool of Clinical Medicine, Tsinghua University, Beijing, 100084, China.
Linkai JingDepartment of Neurosurgery, Changgung Hospital, Clinical Institute for Neuroscience, Medical Center, Tsinghua University, Beijing, 102218, China.
Weitao ManDepartment of Neurosurgery, Changgung Hospital, Clinical Institute for Neuroscience, Medical Center, Tsinghua University, Beijing, 102218, China.
Guihuai WangDepartment of Neurosurgery, Changgung Hospital, Clinical Institute for Neuroscience, Medical Center, Tsinghua University, Beijing, 102218, China. guihuai_wang@163.com.
Beijing Tsinghua Chang Gung Hospital · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal neurocytoma (SN), although frequently reportedly as tumors of the central nervous system (CNS), are a distinct class of tumors, which can achieve a better prognosis following subtotal or gross total tumor resection. Nonetheless, even with the premise of successful treatment after tumor resection, poor prognosis after treatment due to the SN high proliferation index (typically known as atypical SN) have been reported. Over the past two decades, atypical SN was only reported in four pediatric cases, amidst the lingering controversy surrounding its postoperative adjuvant therapy. Thus, herein, we report a unique case of atypical SN with epidermal growth factor receptor (EGFR) amplification mutation in a 12-year-old boy. We, however, also highlighted the significance of radiotherapy and target therapy for patients with SN.

Indexed as

Brain NeoplasmsNeurocytomaChildCombined Modality TherapyErbB ReceptorsHumansMaleMutationPrognosisEGFR protein, humanErbB ReceptorsAtypicalEGFRSpinal neurocytomaTarget therapy

Identifiers

PMID33029729
OpenAlexW3092151013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.