Evidence map›Paper›PMID 33029694›Full record

ArticleEuropean radiology experimental2020

7-T MRI tracking of mesenchymal stromal cells after lung injection in a rat model.

Stefania Rizzo, Francesco Padelli, Elena Rinaldi, Daniela Gioeni, Domenico Aquino, Stefano Brizzola, Fabio Acocella, Lorenzo Spaggiari, Fulvio Baggi, Massimo Bellomi and 2 more

Open access · goldAbstract read
In one paragraph

Article in European radiology experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Direct Cell Radiolabeling forChemical reviews · 2022
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Stefania RizzoImaging Institute of the Southern Switzerland (IIMSI), Ente Ospedaliero Cantonale (EOC), via Tesserete 46, 6900, Lugano, Switzerland. stefania.rizzo@eoc.ch.ORCID 0000-0002-5151-0866
Francesco PadelliNeuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Elena RinaldiNeuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Daniela GioeniDipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy.
Domenico AquinoNeuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Stefano BrizzolaDepartment of Health, Animal Science and Food Safety, Università degli Studi di Milano, Milan, Italy.
Fabio AcocellaDepartment of Health, Animal Science and Food Safety, Università degli Studi di Milano, Milan, Italy.
Lorenzo SpaggiariDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy.
Fulvio BaggiNeuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Massimo BellomiDepartment of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Maria Grazia BruzzoneDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Francesco PetrellaDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy.
University of Milan · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITEnte Ospedaliero Cantonale · CH

Funding

Fondazione IEO (IT) no number
6 · The paper itself

Abstract

backgroundMesenchymal stromal cells (MSCs) are able to migrate and engraft at sites of inflammation, injuries, and tumours, but little is known about their fate after local injection. The purpose of this study is to perform MSC tracking, combining in vivo 7-T magnetic resonance imaging (MRI) and histological assessment, following lung injection in a rat model.

methodsFive lungs were injected with ferumoxide-labelled MSCs and five with perfluorocarbon-labelled MSCs and underwent 7-T MRI. MRI acquisitions were recorded immediately (T

resultsFerumoxide-labelled MSCs were not detectable in the lungs, whereas they were not visible in the distant sites. Perfluorocarbon-labelled MSCs were seen in 5/5 injected lungs at T

conclusionsFerumoxide-labelled cells were not seen at distant sites; a linear decay of injected perfluorocarbon-labelled MSCs was observed at T

Indexed as

Mesenchymal Stem CellsAnimalsCell TrackingDextransImage Processing, Computer-AssistedLungMagnetic Resonance ImagingMagnetite NanoparticlesMesenchymal Stem Cell TransplantationRatsRats, Inbred F344DextransferumoxidesMagnetite NanoparticlesFerumoxidesFluorocarbonsLungMagnetic resonance imagingMesenchymal stromal cells

Identifiers

PMID33029694
PMCPMC7541802
OpenAlexW3092273005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.