ArticleEuropean journal of clinical pharmacology2021
Potentially inappropriate medication in older psychiatric patients.
Article in European journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prevalence and solving strategies of drug-related problems in adult psychiatric inpatients - a systematic review.Frontiers in psychiatry · 2024Pooled it
- Mitigating risk in psychiatric hospital care for older adults by identifying adverse events with Global Trigger Tool for psychiatric patients.The International journal of risk & safety in medicine · 2026Article
- Deprescribing: Reducing Harm, Enhancing Care.Rambam Maimonides medical journal · 2026Review
- Depression and Anxiety Among Patients with COPD: A Nationwide Study from Lithuania.International journal of chronic obstructive pulmonary disease · 2026Observational
- Medication Use and Quality of Life in Older Adults with Personality Disorders.Drugs & aging · 2025Observational
- Comparative Analysis of Drugs Frequently Suspected of Causing Adverse Drug Reactions Reported via the Spontaneous Reporting System Versus in a Prospective Multicentre Cohort Study in Hospital Emergency Departments.Journal of clinical medicine · 2025Article
- Identifying behavior regulatory leverage over mental disorders transcriptomic network hubs toward lifestyle-dependent psychiatric drugs repurposing.Human genomics · 2025Article
- Patterns and Appropriateness of Psychotropic Medications Prescribing in Primary Healthcare in Jordan.Pharmacy (Basel, Switzerland) · 2025Article
- Drug utilization in geriatric psychiatric patients in the emergency department-a cohort study under real-world conditions.Therapeutic advances in psychopharmacology · 2025Article
- Drug safety in older patients with alcohol use disorder: a retrospective cohort study.Therapeutic advances in psychopharmacology · 2024Article
- Association between number of medications and hip fractures in Japanese elderly using conditional logistic LASSO regression.Scientific reports · 2023Article
- Drug Safety Profiles of Geriatric Patients Referred to Consultation Psychiatry in the Emergency Department-A Retrospective Cohort Study.Journal of geriatric psychiatry and neurology · 2023Article
- Prevalence and predictors of inappropriate prescribing in outpatients with severe mental illness.Therapeutic advances in psychopharmacology · 2023Article
- Article
- Potentially inappropriate medications according to PRISCUS list and FORTA (Fit fOR The Aged) classification in geriatric psychiatry: a cross-sectional study.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Geographic Variation in Top-10 Prescribed Medicines and Potentially Inappropriate Medication in Portugal: An Ecological Study of 2.2 Million Older Adults.International journal of environmental research and public health · 2022Article
- Effectiveness of Interventions to Reduce Potentially Inappropriate Medication in Older Patients: A Systematic Review.Frontiers in pharmacology · 2021Review
- Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders.PloS one · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMany psychotropic drugs are listed as potentially inappropriate medication (PIM) in the older population. Potentially inappropriate means that prescription of those drugs in older adults may cause significant harm. The objective of this study was to analyze the prevalence and sort of PIM prescribing in a naturalistic, real-world psychiatric setting.
methodsThe retrospective analysis gathered data from a large pharmacovigilance study, conducted at 10 psychiatric hospitals. Data from inpatients aged ≥ 65 years were included for the analysis. The number and sort of PIM, as defined by the German PRISCUS list, were controlled by analyzing the patients' medication profile.
resultsIn total, 4760 patient cases (59.2% female) with a mean (mean ± standard deviation (SD)) age of 77.33 ± 7.77 years were included into the study. Altogether, 1615 cases (33.9%) received at least 1 PRISCUS-PIM per day (regular and as-needed medication included). The most frequently prescribed PRISCUS-PIM (n = 2144) were zopiclone > 3.75 mg/day (n = 310), lorazepam > 2 mg/day (n = 269), haloperidol > 2 mg/day (n = 252), and diazepam (n = 182). Cases with PRISCUS-PIM were younger (75.7 vs. 78.2 years, p < 0.001) and had a longer (26 vs. 22 days, p < 0.001) hospital length of stay. Replacing benzodiazepines and z-substances, haloperidol > 2 mg, tricyclic antidepressants, first generation antihistaminergic drugs, and clonidine by non-PIM could reduce 69.9% of PRISCUS-PIM-prescribing.
conclusionsThe prevalence of PRISCUS-PIM is high in the hospitalized psychiatric setting. Rational deprescribing of inappropriate anticholinergics, benzodiazepines, and antipsychotics in the older population is a key component to reduce the risk of adverse drug reactions. More tolerable medications should be prescribed.
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