Evidence map›Paper›PMID 33029341›Full record

ArticleStroke research and treatment2020

Effects of Preexisting Psychotropic Medication Use on a Cohort of Patients with Ischemic Stroke Outcome.

Adalia H Jun-O'Connell, Dilip K Jayaraman, Nils Henninger, Brian Silver, Majaz Moonis, Anthony J Rothschild

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Adalia H Jun-O'ConnellDepartments of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID https://orcid.org/0000-0003-0667-2951
Dilip K JayaramanNeurology Department, Tower Health Medical Group, University of Massachusetts Medical School, Worcester, MA, USA.
Nils HenningerDepartments of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
Brian SilverDepartments of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
Majaz MoonisDepartments of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
Anthony J RothschildDepartment of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA.
University of Massachusetts Chan Medical School · US

Funding

Reducing Brain Injury After Focal Ischemia Using a Nitric Oxide-Neutral Oxygen CarrierR44NS076272 · NINDS · OMNIOX, INC. · PI KRTOLICA, ANA, WINGER, JONATHAN A · 2016 to 2017
$2.3M
Inhibiting axon degeneration in a mouse model of acute brain injury through deletion of Sarm1K08NS091499 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2016 to 2020
$919k
NINDS NIH HHS K08 NS091499NINDS NIH HHS R44 NS076272
6 · The paper itself

Abstract

backgroundSeveral studies investigated the use of selective serotonin reuptake inhibitors (SSRI) after ischemic stroke to improve motor recovery. However, little is known about the effects of preexisting psychotropic medication use (PPMU), such as antidepressants, on a long-term ischemic stroke functional disability.

objectiveWe sought to determine the prevalence of PPMU and whether PPMU relates to the long-term clinical outcome in a cohort of patients presenting with acute ischemic strokes.

methodsWe retrospectively analyzed 323 consecutive patients who presented with an acute ischemic stroke in a single institution between January 2015 and December 2017. Baseline characteristics, functional disability as measured by the modified Rankin Scale (mRS), and major adverse cardiovascular complications (MACE) within 365 days were recorded. The comparison groups included a control group of ischemic stroke patients who were not on psychotropic medications before and after the index ischemic stroke and a second group of poststroke psychotropic medication use (PoMU), which consisted of patients started on psychotropic medication during the index admission.

resultsThe prevalence of PPMU in the studied cohort was 21.4% (69/323). There was a greater proportion of females in the PPMU than in the comparison groups (

conclusionPPMU in ischemic stroke is common; it can be beneficial in ischemic stroke in the long-term clinical outcome and is not associated with increased risks of MACE.

Identifiers

PMID33029341
PMCPMC7528134
OpenAlexW3088313720

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.