Evidence map›Paper›PMID 33029326›Full record

ArticleEuropean journal of psychotraumatology2020

Genetic predictors of hippocampal subfield volume in PTSD cases and trauma-exposed controls.

Rajendra A Morey, Melanie E Garrett, Jennifer S Stevens, Emily K Clarke, Courtney C Haswell, Sanne J H van Rooij, Negar Fani, Adriana Lori, Va Mid-Atlantic Mirecc Workgroup, Nathan A Kimbrel and 6 more

Open access · goldAbstract read
In one paragraph

Article in European journal of psychotraumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Rajendra A MoreyVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Melanie E GarrettVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Emily K ClarkeVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Courtney C HaswellVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Adriana LoriDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Va Mid-Atlantic Mirecc WorkgroupVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Nathan A KimbrelVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Michelle F DennisVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Christine E MarxVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Jean C BeckhamVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Gregory McCarthyDepartment of Psychology, Yale University, New Haven, CT, USA.
Michael A HauserVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Allison E Ashley-KochVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA.
Duke University · USEmory University · USDuke Medical Center · USYale University · US

Funding

Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
White Matter Damage in Subconcussive Blast ExposureR01NS086885 · NINDS · DUKE UNIVERSITY · PI MOREY, RAJENDRA A · 2014 to 2018
$1.7M
Gene x Environment Effects on PTSDIK2CX000525 · VA · OLIN TEAGUE VETERANS CENTER · PI KIMBREL, NATHAN A. · 2012 to 2016
–
Imaging-Genetics of PTSD in OEF/OIF VeteransI01CX000120 · VA · DURHAM VA MEDICAL CENTER · PI MOREY, RAJENDRA A · 2009 to 2012
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Group Cognitive Behavioral Therapy for Anger and Aggression in Veterans with PTSDIK2RX001298 · VA · DURHAM VA MEDICAL CENTER · PI VAN VOORHEES, ELIZABETH · 2015 to 2018
–
Combined Smoking Cessation and Cognitive Processing Therapy for PTSDIK2CX000718 · VA · DURHAM VA MEDICAL CENTER · PI DEDERT, ERIC A · 2013 to 2017
–
Brain Systems for Fear Generalization and Threat Processing in PTSDI01CX000748 · VA · DURHAM VA MEDICAL CENTER · PI MOREY, RAJENDRA A · 2014 to 2017
–
CSRD VA I01 CX000120CSRD VA I01 CX000748CSRD VA IK2 CX000525CSRD VA IK2 CX000718NIMH NIH HHS R01 MH111671NINDS NIH HHS R01 NS086885RRD VA IK2 RX001298
6 · The paper itself

Abstract

Behavioural, structural, and functional neuroimaging have implicated the hippocampus as a critical brain region in posttraumatic stress disorder (PTSD) pathogenesis. Recent work in a normative, primarily European, sample identified 15 unique genetic loci contributing to structural variability in six hippocampal subfield volumes. We explored the relevance of these loci in two samples (Mental Illness Research Education and Clinical Centre [MIRECC] and Grady;

Indexed as

childhood trauma• Gene by environment interactions of genetic loci with both PTSD and childhood trauma on hippocampal phenotypesgeneticshippocampal subfieldshippocampusPTSDstructural MRI

Identifiers

PMID33029326
PMCPMC7473168
OpenAlexW3045979388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.